Oliver Florey
Research Summary
Research in our lab is focused on the related topics of autophagy (self eating), macroendocytosis (digestion of extracellular material) and entosis (a recently discovered form of cell cannibalism). These are 3 distinct but inter-related forms of cellular ‘eating’, which play an important role in normal biology and become deregulated during ageing or disease (eg cancer).
Our work exploits a combination of molecular and cellular biology, state-of-the-art microscopy (long-term timelapse imaging, spinning disk confocal and electron microscopy) and proteomics (mass spectrometry).
Existing projects aim to define the molecular mechanisms which underlie cellular eating, with a particular focus on the emerging pathway of non-canonical autophagy. We are also investigating the intriguing relationship between entosis and cancer.
Latest Publications
CDK1, the Other 'Master Regulator' of Autophagy. Trends in cell biology, 1, 1, 30 Nov 2020 PMID: 33272830 |
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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis. Molecular cell, S1097-2765, 19, 06 Nov 2019
DOI:
10.1016/j.molcel.2019.10.016
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Macropinocytosis and autophagy crosstalk in nutrient scavenging. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 374, 1471-2970, 2019 PMID: 30967004 |

B) H&E staining from a human breast carcinoma, arrows point to cell-in-cell structures (taken from Biomax.us).
C) Immunofluorescent staining of b-catenin in a cell-in-cell structure from a human breast tumor.
D) Immunofluorescent staining of E-cadherin in a cell-in-cell structure from MCF10A cells.