Research Groups

Group Leaders

The Babraham Institute’s research focuses on understanding fundamental biology and its role in healthy ageing and disease. Our research groups form three strategic research programmes; Epigenetics, Signalling and Immunology. You can discover more about all our research groups below, and the list includes honorary group leaders and associate group leaders affiliated with a specific research programme. In addition, the Institute operates several scientific facilities. Each facility employs a specialist team with skills and expertise in key cutting-edge research techniques.


Maria Christophorou

Christophorou lab image

How mechanisms that modulate the function of epigenetic regulators are perturbed in disease and how they may be targeted for therapeutic effect. Epigenetics



Simon Cook

The role of protein kinases in cellular responses to growth factors, nutrient availability or stress and damage. Signalling



Anne Corcoran

Understanding the role of chromatin and nuclear organisation in controlling gene expression during the development of the immune system. Associate group leader hosted by Immunology



Della David


Understand the molecular basis of ageing by focusing on protein aggregation - a pathological adaptation to ageing. Signalling



Yiliang Ding


The role of RNA structure in gene regulation with a focus on understanding the dynamics of RNA structure in living cells. Honorary group leader in Immunology



Oliver Florey

The role of autophagy and other cellular ‘eating’ processes in normal biology and during ageing or disease. Signalling



Phill Hawkins

The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks). Signalling



Jon Houseley

The mechanisms by which cells learn to adapt and thrive in new environments. Epigenetics



Martin Howard


Using mathematical modelling to rationalise complex biological dynamics into simple underlying mechanisms. Honorary group leader in Epigenetics



Gavin Kelsey

The epigenetics of the egg and sperm and their role in carrying information between generations. Epigenetics



Nicholas Ktistakis

How autophagy contributes to health and healthy ageing by eliminating damage and recycling cell components. Signalling



Michelle Linterman

Understanding the changes that occur in T cells with age that contribute to the age-dependent decline in the germinal centre response. Immunology



Adrian Liston

The role of regulatory T cells in controlling and suppressing the immune system and the effect of age on these cells. Honorary group leader in Immunology



Ian McGough


How signalling pathways change in ageing organs and how such changes affect organ function. Signalling



Kathy Niakan


Investigating the mechanisms that direct ‘cell fate’ in human embryos and stem cells. Honorary group leader in Epigenetics



Valerie O'Donnell


The study of bioactive lipids in circulating blood cells, particularly platelets. Honorary group leader in Signalling



Teresa Rayon

Rayon research image

How regulatory and dynamic processes control timing in development and homeostasis. Epigenetics and Signalling



Wolf Reik

The role of epigenetics in cell identity and factors involved in the process of epigenetic reprogramming. Honorary group leader in Epigenetics



Claudia Ribeiro de Almeida

The molecular mechanisms underlying diversification of antibody genes by B cells in the immune system. Immunology



Arianne Richard

Arianne Richard research image

How T cells sense and integrate information from both infection and the physiological environment to generate appropriate immune responses. Immunology



Peter Rugg-Gunn

Cell images

The epigenome in stem cells and development, and how epigenetics changes through the life course. Epigenetics



Rahul Samant

Samant sections

Investigating the plasticity of protein clearance pathways in young, aged, and diseased cells. Signalling



Hayley Sharpe

Sharpe sections

Understanding how the cells that make up our tissues and organs communicate. Signalling



Len Stephens

The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks). Signalling



Kai-Michael Toellner

Kai Toellner research image

Studying how lymphocytes respond to vaccination or infection, including the mechanisms of antibody protection, auto-immunity and changes to these mechanisms with age. Immunology.



Sophie Trefely


Providing fundamental insights into the role of nuclear metabolism in ageing and metabolic syndrome. Signalling/Epigenetics



Martin Turner

Gene expression and the roles of RNAs in the development and function of lymphocytes. Immunology



Philipp Voigt


Understanding the molecular mechanisms that control the accurate and timely expression of genes during development. Epigenetics



Heidi Welch

Control of cell shape, movement, gene expression and other factors by Rac-GEF proteins. Associate group leader hosted by Signalling