Group Leaders
The Babraham Institute’s research focuses on understanding fundamental biology and its role in healthy ageing and disease. Our research groups form three strategic research programmes; epigenetics, signalling and lymphocyte signalling. You can discover more about all our research groups below.
In addition, we have a number of affiliated research groups and the Institute operates several scientific facilities. Each facility employs a specialist team with skills and expertise in key cutting-edge research techniques.
Geoff Butcher
Lymphocyte Signalling
Maintaining the immune cell population through lymphocyte homeostasis and the role of GIMAP proteins in this process
Olivia Casanueva
Epigenetics
Mechanisms linked to stress and ageing in C. elegans worms and how they vary between individuals
Maria Christophorou
Epigenetics
How mechanisms that modulate the function of epigenetic regulators are perturbed in disease and how they may be targeted for therapeutic effect
Simon Cook
Signalling
The role of protein kinases in cellular responses to growth factors, nutrient availability or stress and damage
Anne Corcoran
Lymphocyte Signalling
Understanding the role of chromatin and nuclear organisation in controlling gene expression during the development of the immune system
Oliver Florey
Signalling
The role of autophagy and other cellular ‘eating’ processes in normal biology and during ageing or disease
Phill Hawkins
Signalling
The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks)
Jon Houseley
Epigenetics
The mechanisms by which cells learn to adapt and thrive in new environments
Gavin Kelsey
Epigenetics
The epigenetics of the egg and sperm and their role in carrying information between generations
Nicolas Ktistakis
Signalling
How autophagy contributes to health and healthy ageing by eliminating damage and recycling cell components
Michelle Linterman
Lymphocyte Signalling
Understanding the changes that occur in T cells with age that contribute to the age-dependent decline in the germinal centre response
Adrian Liston
Lymphocyte Signalling
The role of regulatory T cells in controlling and suppressing the immune system and the effect of age on these cells
Wolf Reik
Epigenetics
The role of epigenetics in cell identity and factors involved in the process of epigenetic reprogramming
Claudia Ribeiro de Almeida
Lymphocyte Signalling
The molecular mechanisms underlying diversification of antibody genes by B cells in the immune system
Sarah Ross
Lymphocyte Signalling
The effect of factors like oxygen levels on gene expression and regulation in T cells of the immune system
Rahul Roychoudhuri
Lymphocyte Signalling
How tolerance mechanisms in the immune system help to prevent autoimmunity and allergies, and their use in therapies
Peter Rugg-Gunn
Epigenetics
The epigenome in stem cells and development, and how epigenetics changes through the life course
Rahul Samant
Signalling
Investigating the plasticity of protein clearance pathways in young, aged, and diseased cells
Hayley Sharpe
Signalling
Understanding how the cells that make up our tissues and organs communicate
Len Stephens
Signalling
The molecular mechanisms and physiological significance of signalling networks involving phosphoinositide 3-kinases (PI3Ks)
Martin Turner
Lymphocyte Signalling
Gene expression and the roles of RNAs in the development and function of lymphocytes
Michael Wakelam
Signalling
Understanding the essential physiological functions of lipids particularly during healthy ageing
Heidi Welch
Signalling
Control of cell shape, movement, gene expression and other factors by Rac-GEF proteins