Life Sciences Research for Lifelong Health

Martin Turner

Research Summary

The molecular processes which control the development and function of lymphocytes have been extensively studied from the perspective of cell surface receptors and their associated intracellular signalling.

Also, many transcription factors which repress or promote the production of mRNA have been identified as being essential for lymphocyte development and activation.  These studies have revealed that genes, molecules and pathways that are used early in the development of lymphocytes are re-used in fully mature cells as part of the response to infection.

We are developing tools for measuring gene expression in rare cell populations.  We also use genome wide approaches to study RNA turnover and translation and to identify the targets of RNA binding proteins.

We aim to characterise fundamental mechanisms controlling lymphocyte development and function throughout the life-course.  These include understanding the roles of RNA binding proteins in lymphocyte development and activation. 

In the future explaining how these are integrated with signal transduction pathways, microRNA and transcription factor networks will be an important step towards a systems level understanding of immunity.

Key Publications on Current Work

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centres
Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M
Nature Immunology, 1529-2916, , 2018
RNA-binding proteins control gene expression and cell fate in the immune system
Turner M, Díaz-Muñoz MD
Nature Immunology, 2018
PMID: 29348497
Click here to read this publication

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1
Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M
Nature Immunology, 1529-2916, 2017
PMID: 28394372
​Click here to read this publication

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M.
Science (New York, N.Y.), 352, 1095-9203, 453-9, 2016
Abstract          Reprint          Full Text
 

Group Members

Latest Publications

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.

Trulley P, Snieckute G, Bekker-Jensen D

Cell reports
27 2211-1247:2859-2870.e6 (2019)

PMID: 31167133

MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells.

Arbore G, Henley T, Biggins L

Life science alliance
2 2575-1077: (2019)

PMID: 31097471

RNA binding proteins in hematopoiesis and hematological malignancy.

Hodson DJ, Screen M, Turner M

Blood
1528-0020: (2019)

PMID: 30967369

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.

Goossens P, Rodriguez-Vita J, Etzerodt A

Cell metabolism
1932-7420: (2019)

PMID: 30930171

Signalling circuits that direct early B-cell development.

Petkau G, Turner M

The Biochemical journal
476 1470-8728:769-778 (2019)

PMID: 30842310

The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis.

Bye-A-Jee H, Pugazhendhi D, Woodhouse S

Skeletal muscle
8 2044-5040:37 (2018)

PMID: 30526691

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells.

Salerno F, Engels S, van den Biggelaar M

Nature immunology
1529-2916: (2018)

PMID: 29988089

Antigen phagocytosis by B cells is required for a potent humoral response.

Martínez-Riaño A, Bovolenta ER, Mendoza P

EMBO reports
1469-3178: (2018)

PMID: 29987136

Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.

Díaz-Muñoz MD, Turner M

Frontiers in immunology
9 1664-3224:1094 (2018)

PMID: 29875770

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.

Monzón-Casanova E, Screen M, Díaz-Muñoz MD

Nature immunology
1529-2916: (2018)

PMID: 29358707

RNA-binding proteins control gene expression and cell fate in the immune system.

Turner M, Díaz-Muñoz MD

Nature immunology
1529-2916: (2018)

PMID: 29348497