Life Sciences Research for Lifelong Health

Martin Turner

Research Summary

The molecular processes which control the development and function of lymphocytes have been extensively studied from the perspective of cell surface receptors and their associated intracellular signalling.

Also, many transcription factors which repress or promote the production of mRNA have been identified as being essential for lymphocyte development and activation.  These studies have revealed that genes, molecules and pathways that are used early in the development of lymphocytes are re-used in fully mature cells as part of the response to infection.

We are developing tools for measuring gene expression in rare cell populations.  We also use genome wide approaches to study RNA turnover and translation and to identify the targets of RNA binding proteins.

We aim to characterise fundamental mechanisms controlling lymphocyte development and function throughout the life-course.  These include understanding the roles of RNA binding proteins in lymphocyte development and activation. 

In the future explaining how these are integrated with signal transduction pathways, microRNA and transcription factor networks will be an important step towards a systems level understanding of immunity.

Latest Publications

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centres
Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M
Nature Immunology, 1529-2916, , 2018
RNA-binding proteins control gene expression and cell fate in the immune system
Turner M, Díaz-Muñoz MD
Nature Immunology, 2018
PMID: 29348497
Click here to read this publication


Recent Publications

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1
Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M
Nature Immunology, 1529-2916, 2017
PMID: 28394372
​Click here to read this publication

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M.
Science (New York, N.Y.), 352, 1095-9203, 453-9, 2016
Abstract          Reprint          Full Text
 

Group Members

Latest Publications

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells.

Salerno F, Engels S, van den Biggelaar M

Nature immunology
1529-2916: (2018)

PMID: 29988089

Antigen phagocytosis by B cells is required for a potent humoral response.

Martínez-Riaño A, Bovolenta ER, Mendoza P

EMBO reports
1469-3178: (2018)

PMID: 29987136

Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.

Díaz-Muñoz MD, Turner M

Frontiers in immunology
9 1664-3224:1094 (2018)

PMID: 29875770

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Nicolas A, Kenna KP, Renton AE

Neuron
97 1097-4199:1268-1283.e6 (2018)

PMID: 29566793

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.

Monzón-Casanova E, Screen M, Díaz-Muñoz MD

Nature immunology
1529-2916: (2018)

PMID: 29358707

RNA-binding proteins control gene expression and cell fate in the immune system.

Turner M, Díaz-Muñoz MD

Nature immunology
1529-2916: (2018)

PMID: 29348497

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.

Díaz-Muñoz MD, Kiselev VY, Novère NL

Nature communications
8 2041-1723:530 (2017)

PMID: 28904350

RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.

Tarling EJ, Clifford BL, Cheng J

The Journal of clinical investigation
1558-8238: (2017)

PMID: 28891815

Characterization of the B Cell Transcriptome Bound by RNA-Binding Proteins with iCLIP.

Díaz-Muñoz MD, Monzón-Casanova E, Turner M

Methods in molecular biology (Clifton, N.J.)
1623 1940-6029:159-179 (2017)

PMID: 28589356

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

Newman R, Ahlfors H, Saveliev A

Nature immunology
1529-2916: (2017)

PMID: 28394372

Cell cycle RNA regulons coordinating early lymphocyte development.

Galloway A, Turner M

Wiley interdisciplinary reviews. RNA
1757-7012: (2017)

PMID: 28231639