Martin Turner

Martin Turner
Martin Turner
Martin Turner
Head of Programme
Martin Turner

Research Summary

The molecular processes which control the development and function of lymphocytes have been extensively studied from the perspective of cell surface receptors and their associated intracellular signalling.

Also, many transcription factors which repress or promote the production of mRNA have been identified as being essential for lymphocyte development and activation.  These studies have revealed that genes, molecules and pathways that are used early in the development of lymphocytes are re-used in fully mature cells as part of the response to infection.

We are developing tools for measuring gene expression in rare cell populations.  We also use genome wide approaches to study RNA turnover and translation and to identify the targets of RNA binding proteins.

We aim to characterise fundamental mechanisms controlling lymphocyte development and function throughout the life-course.  These include understanding the roles of RNA binding proteins in lymphocyte development and activation. 

In the future explaining how these are integrated with signal transduction pathways, microRNA and transcription factor networks will be an important step towards a systems level understanding of immunity.

 

Key Publications on Current Work

 

A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

Open Access symbol

Turner DJ, Saveliev A, Salerno F, Matheson LS, Screen M, Lawson H, Wotherspoon D, Kranc KR, Turner M
ELIFE, 2022
PMID: 35451955


 

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins.

Open Access symbol

Petkau G, Mitchell TJ, Chakraborty K, Bell SE, D'Angeli V, Matheson L, Turner DJ, Saveliev A, Gizlenci O, Salerno F, Katsikis PD, Turner M
Nature Communications, 2022
PMID: 35477960


 

Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1

Open Access symbol

Saveliev A, Bell SE, Turner M
The Journal of experimental medicine, 2021
PMID: 33306108


 

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centres

Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M
Nature Immunology, 2018
PMID: 29358707


 

RNA-binding proteins control gene expression and cell fate in the immune system

Turner M, Díaz-Muñoz MD
Nature Immunology, 2018
PMID: 29348497


 

Martin's Twitter Feed

Preprints

The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition
David J. Turner, Alexander Saveliev, Fiamma Salerno, Louise S. Matheson, Michael Screen, Hannah Lawson, David Wotherspoon, Kamil R. Kranc, Martin Turner

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins
Georg Petkau, Twm J. Mitchell, Krishnendu Chakraborty, Sarah E. Bell, Vanessa D’Angeli, Louise Matheson,  David J. Turner,  Ozge Gizlenci,  Fiamma Salerno,  Peter D. Katsikis,  Martin Turner

ORFLine: a bioinformatic pipeline to prioritise small open reading frames identifies candidate secreted small proteins from lymphocytes.
Fengyuan Hu, Jia Lu, Manuel D. Munoz, Alexander Saveliev, Martin Turner

Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell
Louise Matheson, Georg Petkau, Beatriz Sáenz-Narciso, Vanessa D’Angeli, Jessica McHugh, Rebecca Newman, Haydn Munford, James West, Krishnendu Chakraborty, Jennie Roberts, Sebastian Łukasiak, Manuel Díaz-Muñoz, Sarah Bell, Sarah Dimeloe, Martin Turner

Group Members

Martin Turner

Head of Programme

Sarah Bell

Senior Research Associate

Ozge Gizlenci

Postdoc Research Scientist

Tahmid Hussain

PhD Student

Marian Jones Evans

PhD Student

Twm Mitchell

Postdoc Research Scientist

Georg Petkau

Postdoc Research Scientist

Beatriz Saenz

Postdoc Research Scientist

Fiamma Salerno

EMBO Fellow

Alexander Saveliev

Postdoc Research Scientist

Michael Screen

Postdoc Research Scientist