The molecular processes which control the development and function of lymphocytes have been extensively studied from the perspective of cell surface receptors and their associated intracellular signalling.
Also, many transcription factors which repress or promote the production of mRNA have been identified as being essential for lymphocyte development and activation. These studies have revealed that genes, molecules and pathways that are used early in the development of lymphocytes are re-used in fully mature cells as part of the response to infection.
We are developing tools for measuring gene expression in rare cell populations. We also use genome wide approaches to study RNA turnover and translation and to identify the targets of RNA binding proteins.
We aim to characterise fundamental mechanisms controlling lymphocyte development and function throughout the life-course. These include understanding the roles of RNA binding proteins in lymphocyte development and activation.
In the future explaining how these are integrated with signal transduction pathways, microRNA and transcription factor networks will be an important step towards a systems level understanding of immunity.
EFFICIENT HOMING OF ANTIBODY-SECRETING CELLS TO THE BONE MARROW REQUIRES RNA-BINDING PROTEIN ZFP36L1
Saveliev A, Bell SE, Turner M
The Journal of experimental medicine, 218, 3, 01 Mar 2021
POLYPYRIMIDINE TRACT BINDING PROTEINS ARE ESSENTIAL FOR B CELL DEVELOPMENT
Monzón-Casanova E, Matheson LS, Tabbada K, Zarnack K, Smith CW, Turner M
eLife, 9, 1, 21 Feb 2020
THE RNA-BINDING PROTEIN PTBP1 IS NECESSARY FOR B CELL SELECTION IN GERMNAL CENTRES
Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M
Nature Immunology, 1529-2916, 2018
RNA-BINDING PROTEINS CONTROL GENE EXPRESSION AND CELL FATE IN THE IMMUNE SYSTEM
Turner M, Díaz-Muñoz MD
Nature Immunology, 2018
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The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition
David J. Turner, Alexander Saveliev, Fiamma Salerno, Louise S. Matheson, Michael Screen, Hannah Lawson, David Wotherspoon, Kamil R. Kranc, Martin Turner
The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins
Georg Petkau, Twm J. Mitchell, Krishnendu Chakraborty, Sarah E. Bell, Vanessa D’Angeli, Louise Matheson, David J. Turner, Ozge Gizlenci, Fiamma Salerno, Peter D. Katsikis, Martin Turner
ORFLine: a bioinformatic pipeline to prioritise small open reading frames identifies candidate secreted small proteins from lymphocytes.
Fengyuan Hu, Jia Lu, Manuel D. Munoz, Alexander Saveliev, Martin Turner