Life Sciences Research for Lifelong Health

Adrian Liston

Research Summary

The Liston laboratory works on regulatory T cells. These are a type of white blood cell that act to suppress the rest of the immune response, preventing spontaneous autoimmune disease and acting as a rheostat to control just how active our immune system is. The number of these cells in our blood goes up as we get old, which may contribute to the immune-supressed state of older persons. We seek to understand these cells, using both patient material and mouse models, so that we can harness their power to fine-tune the immune system for healthy ageing.

Latest Publications

Inborn errors of immunity: single mutations unravel mechanisms of immune disease.
Liston A, Humblet-Baron S

Immunology and cell biology, , 1440-1711, , 2019

PMID: 30942931

The Aire family expands.
Liston A, Dooley J

T cell tolerance depends upon Aire-expressing cells to purge the T cell repertoire of autoreactive clones. Once thought to be the exclusive domain of thymic epithelial cells, a new study by Yamano et al. (https://doi.org/10.1084/jem.20181430) in this issue of identifies ILC3-like cells in the lymph nodes with similar properties.

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The Journal of experimental medicine, , 1540-9538, , 2019

PMID: 30923044

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.
Van Nieuwenhove E, Lagou V, Van Eyck L, Dooley J, Bodenhofer U, Roca C, Vandebergh M, Goris A, Humblet-Baron S, Wouters C, Liston A

Juvenile idiopathic arthritis (JIA) is the most common class of childhood rheumatic diseases, with distinct disease subsets that may have diverging pathophysiological origins. Both adaptive and innate immune processes have been proposed as primary drivers, which may account for the observed clinical heterogeneity, but few high-depth studies have been performed.

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Annals of the rheumatic diseases, , 1468-2060, , 2019

PMID: 30862608

Group Members

Latest Publications

Inborn errors of immunity: single mutations unravel mechanisms of immune disease.

Liston A, Humblet-Baron S

Immunology and cell biology
1440-1711: (2019)

PMID: 30942931

The Aire family expands.

Liston A, Dooley J

The Journal of experimental medicine
1540-9538: (2019)

PMID: 30923044

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.

Van Nieuwenhove E, Lagou V, Van Eyck L

Annals of the rheumatic diseases
1468-2060: (2019)

PMID: 30862608

Prospective study evaluating immune-mediated mechanisms and predisposing factors underlying persistent postinfectious abdominal complaints.

Florens MV, Van Wanrooy S, Dooley J

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
31 1365-2982:e13542 (2019)

PMID: 30657233

IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis.

Humblet-Baron S, Franckaert D, Dooley J

The Journal of allergy and clinical immunology
1097-6825: (2018)

PMID: 30578871

NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology.

Schlenner S, Pasciuto E, Lagou V

Annals of the rheumatic diseases
78 1468-2060:342-349 (2019)

PMID: 30552177

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V, Garcia-Perez JE, Smets I

Cell reports
25 2211-1247:798-810.e6 (2018)

PMID: 30332657

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.

van Nieuwenhuijze A, Burton O, Lemaitre P

Frontiers in immunology
9 1664-3224:2234 (2018)

PMID: 30323813

The Long Non-coding RNA Anticipates Foxp3 Expression in Regulatory T Cells.

Brajic A, Franckaert D, Burton O

Frontiers in immunology
9 1664-3224:1989 (2018)

PMID: 30319599

Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.

Imbrechts M, Avau A, Vandenhaute J

Journal of immunology (Baltimore, Md. : 1950)
201 1550-6606:2654-2663 (2018)

PMID: 30266771