Image PrizeEach year members of the Institute can put forward images for the Imaging Prize, usually created using the Institute's Imaging Facility.
The winner is selected by everyone in the Institute through a public vote.
C. elegans worms labelled with a fluorescent protein and imaged using a confocal microscope. C. elegans is a really useful system for our research because we can monitor fluorescent reporters of gene expression in vivo and study inter-individual variability in stress response gene expression in isogenic individuals.
This image shows the lining of the large intestine. DNA in the cell nuclei is shown in red. Histone-crotonylation, an epigenetic mark involved in gene activation, is shown in green. Yellow indicates colocalization of both stainings.
This is a cross-section through a mouse’s colonic epithelium. It is folded into so-called crypts to form a large surface area for the absorption of water and nutrients, and is covered by a protective mucous layer. This layer is secreted by goblet cells which are shown in red. These cells are crammed with mucins, proteins which make up the protective mucus and which were stained for using red fluorescent antibodies. (blue = DAPI staining nuclei, green = anti-EpCAM antibodies staining the cell membrane of epithelial cells)
A cross section of left ventricle of an adult rat heart. Cardiac muscle fibre actinin is in red, identifying the muscle cells from fibroblasts. In addition, cardiac myocyte nuclei have a ring of green around their periphery. This is pericentriolar material-1 and is used to isolate myocyte nuclei from a total heart nuclear extraction. All nuclei are stained in blue.