Dr Pawel Swietach; Department of Physiology, Anatomy and Genetics, University of Oxford
Pawel studied physiological sciences in Oxford and completed a PhD in cardiovascular physiology. Held a University Research Fellowship, MRC New Investigator Award and ERC Consolidator Award. Works at the intersection of physiology, signalling and metabolism.
Cellular metabolism is increasingly recognised not only as a source of energy but as a direct regulator of gene expression. Recent work demonstrates that disruption of propionate metabolism alters the epigenetic landscape of the heart by increasing histone acylation, including acetylation and propionylation. These modifications reshape transcriptional programs and drive functional changes in cardiac tissue, linking metabolic imbalance to disease-relevant phenotypes. This seminar will explore how metabolic intermediates act as signalling molecules to control chromatin state, the mechanisms by which propionate influences gene regulation, and the broader implications for understanding metabolic contributions to cardiovascular disease.
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