Prof Dame Linda Partridge; University College London
Linda Partridge works on the biology of ageing. Her research is directed to understanding the mechanisms by which the healthy period of life can be extended in laboratory model organisms and in humans. She has focussed on the role of the nutrient-sensing signalling network and of diet. Her primary current interest is in the potential to repurpose drugs for geroprotection. She is the recipient of numerous awards. She is a Fellow of the Royal Society, the Academy of Medical Sciences and a foreign member of the American Academy of Arts and Sciences and the German Academy of Sciences Leopoldina. She is the emeritus founding director of the Max Planck Institute for Biology of Ageing in Cologne, Germany.
Hallmarks of ageing are present in the aetiology of human age-related diseases and they can partly explain patterns of disease co-occurrence. There is marked inequality in heath during ageing, with social deprivation accelerating the incidence of diseases associated with specific ageing hallmarks. These findings support the geroscience hypothesis, that human health during ageing could be improved by targeting mechanisms of ageing. We have been investigating two potentially geroprotective drugs, rapamycin and trametinib, and find that they are especially geroprotective in combination, in both Drosophila and mice. Reduced inflammation appears to play a prominent role, and warrants more detailed study.
Following the talk will be tea, coffee, cake and networking.
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