Cellular mechanisms of embryonic development and dormancy

Cellular mechanisms of embryonic development and dormancy

Dr Ivan Bedzhov; Max Planck Institute for Molecular Biomedicine

Since 2015 Principal Investigator - Max Planck Institute for Molecular Biomedicine, Munster, Germany 2012-2015 Postdoc - WT/CRUK Gurdon Institute & Department of Physiology, Development and Neuroscience, University of Cambridge, UK 2007-2011 PhD student -Max Planck Institute for Immunobiology and Epigenetics, Department of Molecular Embryology, Freiburg, Germany 2004-2006 MSc studies - Genetic and cell engineering, University of Sofia, Bulgaria 2000-2004 BSc studies - Molecular biology, University of Sofia, Bulgaria.

The mammalian embryo establishes the first direct contact with the maternal tissues during implantation. As the blastocyst attaches to the uterine wall, it transforms into a post-implantation conceptus, laying the foundations for placentation and foetal development. In some species, including mice, this process is suspended in a non-receptive uterine environment, where embryonic development arrests at the blastocyst stage and the embryo enters a dormant state known as diapause. In this state, the embryo relies on poorly understood regulatory mechanisms to maintain its viability and developmental potential over long periods of time.

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