Mahrukh Shameem

Mahrukh Shameem wearing sunglasses and a jumper with sheep on

I earned my PhD from the University of Sheffield in partnership with AstraZeneca, under the supervision of Dr. Simon Johnston and Dr. Suzanne Cohen. My research investigated how interleukin-33 contributes to the early innate immune response during respiratory infections and inflammation, primarily utilising imaging techniques. This project explored the therapeutic potential of inhibiting this protein to treat chronic inflammatory conditions such as asthma. This experience gave me a solid understanding of how macrophages and neutrophils initiate and coordinate immune responses. It fuelled my interest in cellular dynamics and interactions, prompting me to seek a role centred on macrophage interactions and their modulation of immune cell responses.

I am currently a postdoctoral training researcher in Professor Kai-Michael Toellner's lab. My research focuses on characterising macrophage-B cell interactions and the implications for B cell development. Ultimately, this research aims to support vaccine development.