- Our Research
- Signalling
- Hayley Sharpe
- Members
- Healthy Ageing
- Group Leaders
- Epigenetics
- Lymphocyte Signalling
- Signalling
- Affiliated Scientists
- Animal Research
- Annual Research Report
- Research Features
- Our Research Explained
- Glossary
Latest Publications
Vismodegib resistant mutations are not selected in multifocal relapses of locally advanced basal cell carcinoma after vismodegib discontinuation.
Ighilahriz M, Benfodda M, Sharpe H
Journal of the European Academy of Dermatology and Venereology : JEADV
1468-3083: (2019)
PMID: 31187903
The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.
Fearnley GW, Young KA, Edgar JR
eLife
8 2050-084X: (2019)
PMID: 30924770
Grking the Smoothened signal.
Sharpe HJ, de Sauvage FJ
Science signaling
11 1937-9145: (2018)
PMID: 29438011
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
Bonilla X, Parmentier L, King B
Nature genetics
48 1546-1718:398-406 (2016)
PMID: 26950094
Regulation of the oncoprotein Smoothened by small molecules.
Sharpe HJ, Wang W, Hannoush RN
Nature chemical biology
11 1552-4469:246-55 (2015)
PMID: 25785427
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
Sharpe HJ, Pau G, Dijkgraaf GJ
Cancer cell
27 1878-3686:327-41 (2015)
PMID: 25759019
Efficacy of Hedgehog pathway inhibitors in Basal cell carcinoma.
Basset-Seguin N, Sharpe HJ, de Sauvage FJ
Molecular cancer therapeutics
14 1538-8514:633-41 (2015)
PMID: 25585509
A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.
Herzig Y, Sharpe HJ, Elbaz Y
PLoS biology
10 1545-7885:e1001329 (2012)
PMID: 22629230
Signaling: An oxysterol ligand for Smoothened.
Sharpe HJ, de Sauvage FJ
Nature chemical biology
8 1552-4469:139-40 (2012)
PMID: 22257852
A comprehensive comparison of transmembrane domains reveals organelle-specific properties.
Sharpe HJ, Stevens TJ, Munro S
Cell
142 1097-4172:158-69 (2010)
PMID: 20603021
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.
Strisovsky K, Sharpe HJ, Freeman M
Molecular cell
36 1097-4164:1048-59 (2009)
PMID: 20064469