The Babraham Distinguished Seminar Series is sponsored by the Babraham Institute and the Babraham Research Campus which is home to more than 50 biotech companies. The seminars are also advertised to the wider Cambridge community. The series will provide exciting science talks by distinguished scientists from across the world in many areas of biomedical interest.
Prof Harald Alfred Stenmark; University of Oslo
Harald Stenmark is professor at University of Oslo, where he is director of a Norwegian Centre of Excellence, Centre for Cancer Cell Reprogramming. He is also Head of Department of Molecular Cell Biology at Institute for Cancer Research, Oslo University Hospital. Stenmark obtained his PhD degree in cell biology at University of Oslo and was a postdoc at European Molecular Biology Laboratory in Heidelberg, . He has held various research positions at University of Oslo and Oslo University Hospital. Stenmark has published some 300 papers in the fields of cellular membrane dynamics and basic cancer research, with special emphasis on the functions of Rab GTPases, phosphoinositides and ESCRT proteins in regulation of endocytosis, autophagy, cell signalling, cell migration, cell division, and membrane repair.
Damaged lysosomes are harmful to cells and participate in propagation of neurotoxic protein aggregates. Recent studies have shown that damaged lysosomes can be repaired by several alternative mechanisms. In our group we have been characterizing lysosome repair mediated by endosomal sorting complex required for transport (ESCRT) proteins and lipids transferred from the endoplasmic reticulum. In my presentation I will discuss our recent findings regarding possible cooperations between these mechanisms and the molecular machinery of lysophagy - autophagic degradation of damaged lysosomes.
Following the talk will be tea, coffee, cake and networking.
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