Translational control in differentiation and development

Translational control in differentiation and development

Professor Danny Nediakova; Max Planck Institute

Danny received a doctorate in molecular virology from Leiden University (The Netherlands) and performed postdoctoral work on tRNA modifications at the Max Planck Institute for Molecular Biomedicine (Germany). Since 2017, she leads the “Mechanisms of Protein Biogenesis” laboratory at the Max Planck Institute of Biochemistry and holds a joint appointment as a tenure-track professor at the Department of Bioscience of the Technical University of Munich (Germany). She received an ERC Starting Grant in 2019 and an EMBO Young Investigator Award in 2022.

Cellular homeostasis depends on the timely and accurate biogenesis of a wide range of proteins by mRNA translation. As the most errorprone step of gene expression, mRNA translation is also monitored by a suite of quality control pathways, which detect and rescue stalled or collided ribosomes to protect cells from potentially toxic aberrant proteins. Our research seeks to define how these fundamental cellular processes are regulated to match distinct and rapidly changing proteome demands during development and cell differentiation. We address these questions at a systems level with genome-wide techniques and functional genomics in diverse eukaryotic model systems. One of our main interests is understanding how tRNA repertoires are dynamically regulated across cell types and states. Our recent work using newly developed technologies in stem cell-based models defined the regulatory rules of tRNA expression and its impact on mRNA decoding during human cell differentiation.

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