Professor Julia Cordero; University of Glasgow
After completing her University studies in her home country of Argentina, Julia moved to the USA to her PhD studies in the laboratory of Ross Cagan at Washington University in St Louis where she studied developmental tissue patterning in Drosophila. In 2009, Julia moved to Owen Sansom’s group at the CRUK Beatson Institute in Glasgow for her postdoctoral work, funded by Marie-Curie and EMBO long-term fellowships. During her post-doc Julia discovered novel mechanisms driving intestinal regeneration and cancer using both flies and mice. Julia started her independent research group towards the end of 2014 at the Institute of Cancer Sciences, University of Glasgow, funded by a Dorothy Hodgkin Fellowship from the Royal Society, a Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society and, most recently, a Wellcome Trust Senior Research Fellowship. Her lab is investigating local and systemic functions of the adult intestine in health and disease.
The adult intestine is a major barrier epithelium and coordinator of multi-organ functions. Stem cells constantly repair the intestinal epithelium by adjusting their proliferation and differentiation to tissue intrinsic as well as micro- and macro-environmental signals. How these signals integrate to control intestinal and whole-body homeostasis is largely unknown. Addressing this gap in knowledge is central to an improved understanding of intestinal pathophysiology and its systemic consequences. Combining Drosophila and mammalian model systems my laboratory studies fundamental mechanisms driving intestinal regeneration and tumourigenesis including complex inter-organ signaling, which I will discuss during my seminar including: 1- Interactions between the intestine and its microenvironment influencing intestinal regeneration and tumourigenesis. 2- Impact of changes in intestinal homeostasis to whole-body physiology.
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