Secret Life of Copper: From Kinases to Cancer

Dr Donita C. Brady

Perelman School of Medicine,

University of Pennsylvania, USA

The Brady Lab researches metalloallostery, a new paradigm in nutrient sensing and protein regulation, where redox-active metals control kinase activity. Their focus lies at the intersection of kinase signaling and copper (Cu) homeostasis with the goal of defining the mechanistic features of Cu-dependent kinases to target them in cancer via drug repurposing or development.

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