Ethical ReviewIn the context of animal use, research at the Institute falls into four categories:
- Research that does not require living tissue, such as computer modelling or molecular analysis such as the study of DNA.
- Research that uses the culture of tissues or cells originally sourced from live animals, including human donors.
- Research using non-vertebrate species such as yeast, nematode worms and fruit flies when it is necessary to study or utilise biological responses than cannot be reproduced in tissue culture.
- Where there are no other alternatives, research involving live vertbrate animals (exclusively rodents) which are classifed as protected species under the Animals (Scientific procedures) Act in UK law.
Review by the AWERB committee compares the potential benefits of the proposed experiments with the likely costs in terms of any possible animal suffering. The following points are considered:
Needs and benefits
- Is the research relevant to human or animal health and/or to understanding basic biology?
- Could it improve the understanding of normal ageing or diseases of ageing?
- The prevalence and severity of any related clinical problem; for example, the health impact and the number of patients suffering from a disease.
- The potential to open up new areas of knowledge.
- Potential improvements to animal or human welfare resulting from the science.
- The number of animals involved in the experiments.
- Actual or potential pain, suffering, distress or lasting harm to experimental animals and their expected severity.
- The cumulative experience throughout the lifetime of an experimental animal.
- Effects on the animals’ natural behaviour and environment, such as transporting animals or altering social groups.