Life Sciences Research for Lifelong Health
Len Stephens' and Phill Hawkins' research group

Group Members

Dr Phill Hawkins

view
Dr Karen Anderson

view
Dr Tamara Chessa

view
Mr Danny Collins

view
Mr Keith Davidson

view
Dr Vishnu Janardan

view
Mr Piotr Jung

view
Dr Sabine Suire

view
Dr Michael Wilson

view

Latest Publications

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T

Proceedings of the National Academy of Sciences of the United States of America
115 1091-6490:12176-12181 (2018)

PMID: 30442661

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J

Biochimica et biophysica acta
0006-3002: (2018)

PMID: 29902570

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ

Blood advances
1 2473-9529:918-932 (2017)

PMID: 29242851

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T

Molecular cell
1097-4164: (2017)

PMID: 29056325

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT

Cancers
9 : (2017)

PMID: 28273837

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR

Journal of immunology (Baltimore, Md. : 1950)
198 1550-6606:1285-1296 (2017)

PMID: 28039302

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27601656

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.

Houslay DM, Anderson KE, Chessa T

Science signaling
9 1937-9145:ra82 (2016)

PMID: 27531651