Life Sciences Research for Lifelong Health

Michelle Linterman

When higher organisms are infected by pathogens the immune system responds with the coordinated activation of many different cell types, each with their own specific role to bring about pathogen clearance, and subsequently generate immunological memory. Within the adaptive immune system helper CD4+ T cells and B cells specific for the infectious organism are recruited to become activated effector cells and a proportion of these cells will go on to become memory cells that are able to respond quickly to future infections.

Germinal centres are sites within tissues such as the tonsils, spleen and lymph nodes where B cells proliferate and differentiate during a normal immune response to an infection. Because of the central role of the germinal centre in generating immunological memory, a potent germinal centre response is critical for a successful response to vaccination. With advancing age, the size of the germinal centre response and the efficacy of vaccination diminish, and T cells are one of the primary contributors to this decline.

Our research is focused on understanding the cellular and molecular changes that occur in T cells with age that contribute to the age-dependent decline in the germinal centre response.

 

Group Members

Latest Publications

Can follicular helper T cells be targeted to improve vaccine efficacy?

Linterman MA, Hill DL

F1000Research
5 2046-1402: (2016)

PMID: 26989476

Follicular Helper T Cells.

Vinuesa CG, Linterman MA, Yu D

Annual review of immunology
1545-3278: (2016)

PMID: 26907215

The cellular composition of the human immune system is shaped by age and cohabitation.

Carr EJ, Dooley J, Garcia-Perez JE

Nature immunology
1529-2916: (2016)

PMID: 26878114

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.

Aloulou M, Carr EJ, Gador M

Nature communications
7 2041-1723:10579 (2016)

PMID: 26818004

Premature thymic involution is independent of structural plasticity of the thymic stroma.

Franckaert D, Schlenner SM, Heirman N

European journal of immunology
1521-4141: (2015)

PMID: 25627671

Regulatory T cells and control of the germinal centre response.

Vanderleyden I, Linterman MA, Smith KG

Arthritis research & therapy
16 1478-6362:471 (2014)

PMID: 25606598

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3(+) and Foxp3(-) T cells.

Franckaert D, Dooley J, Roos E

Immunology and cell biology
1440-1711: (2014)

PMID: 25533288

Treg cells and CTLA-4: the ball and chain of the germinal center response.

Linterman MA, Denton AE

Immunity
41 1097-4180:876-8 (2014)

PMID: 25526300

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espeli M,Smith KG

eLife
3 2050-084X: (2014)

PMID: 25347065

Cellular Plasticity of CD4+ T Cells in the Intestine.

V Brucklacher-Waldert, EJ Carr, MA Linterman

Frontiers in immunology
5 1664-3224:488 (2014)

PMID: 25339956

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers.

Wallin EF, Jolly EC, Suchánek O

Blood
124 1528-0020:2666-74 (2014)

PMID: 25224411

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells.

Denton AE, Roberts EW, Linterman MA

Proceedings of the National Academy of Sciences of the United States of America
111 1091-6490:12139-44 (2014)

PMID: 25092322