Life Sciences Research for Lifelong Health

Lymphocyte Signalling

Lymphocyte Signalling

The study of the processes that regulate the development, survival and function of white blood cells

The primary goals of the immune system are to protect the body against invading pathogens and prevent subsequent infection. This powerful system must be carefully balanced to ensure that it does not destroy the body it has evolved to protect. We use a multidisciplinary approach to investigate the receptors and pathways that regulate lymphocyte development and activation. Lymphocytes are a subset of white blood cells and can be divided into three main classes: T cells, which develop in the thymus mediate cell-mediated immunity and help B cells generate antibodies; B cells, which develop in the bone marrow and mediate humoral immunity by secreting antibodies; innate lymphocytes, which do not express T cell or B cell receptors for antigen, but play essential roles early in an infection. Each class of lymphocyte functionally interacts with the others to mount an immune response.

Lymphocyte Signalling at a glance

Up to 90 autoimmune diseases (including multiple sclerosis, rheumatoid arthritis and type-1 diabetes),100 inherited immune deficiencies and reduced immune function are due to ageing.
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A greater understanding of immunity is central to the goal of promoting a healthier lifespan. We aim to understand the processes that regulate the development, survival and function of lymphocytes.
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We have identified genes responsible for regulating lymphocyte development and will uncover the mechanisms by which these genes function to allow the cells to mature and survive.
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This is essential to improve vaccines, combat autoimmune diseases, develope tumour immunotherapy or improve the efficiency of organ transplantation
Decoding the molecular mechanisms regulating lymphocyte maturation and function is essential to improve vaccines, combat autoimmune disease, develop tumour immunotherapy or improve the efficiency of organ transplantation. With up to 90 autoimmune diseases (including multiple sclerosis, rheumatoid arthritis and type 1 diabetes), 100 inherited immune deficiencies and reduced immune function due to ageing, a greater understanding of immunity is central to the goal of promoting a healthier lifespan. We have identified genes responsible for regulating lymphocyte development and will uncover the mechanisms by which these genes function to allow the cells to mature and survive during life. 
 

Research Impact

Industrial Research Collaborations - 19

CASE PhD Studentships - 5

Formal Industrial Consultancy Agreements - 4

Group Leaders