Life Sciences Research for Lifelong Health

Lymphocyte Signalling

Lymphocyte Signalling

The study of the processes that regulate the development, survival and function of white blood cells

The primary goals of the immune system are to protect the body against invading pathogens and prevent subsequent infection. This powerful system must be carefully balanced to ensure that it does not destroy the body it has evolved to protect. We use a multidisciplinary approach to investigate the receptors and pathways that regulate lymphocyte development and activation. Lymphocytes are a subset of white blood cells and can be divided into three main classes: T cells, which develop in the thymus mediate cell-mediated immunity and help B cells generate antibodies; B cells, which develop in the bone marrow and mediate humoral immunity by secreting antibodies; innate lymphocytes, which do not express T cell or B cell receptors for antigen, but play essential roles early in an infection. Each class of lymphocyte functionally interacts with the others to mount an immune response.

Lymph node cells

A greater understanding of immunity is central to the goal of promoting a healthier lifespan. We aim to understand the processes that regulate the development, survival and function of lymphocytes.
Tis11b - a component of processing bodies

We have identified genes responsible for regulating lymphocyte development and will uncover the mechanisms by which these genes function to allow the cells to mature and survive.
CD8 circulating lymphoblasts

This is essential to improve vaccines, combat autoimmune diseases, develop tumour immunotherapy or improve the efficiency of organ transplantation


Weapons of Microscopic Destruction at the Brighton Science Festival

Brighton Science Festival - 13th and 14th February


B cell trafficking and activation in the splenic environment

Dr Tal Arnon - The Kennedy Institute of Rheumatology, University…


CD4 T cell help for humoral immunity in transplantation

Dr Gavin Pettigrew; Department of Surgery, School of Clinical…


A testing time: understanding more about how the ‘best’ B cells are selected

Paper published in Journal of Clinical Investigation

Role of microRNA-155 in affinity-based antibody selection


Public encourage Institute to protect fundamental bioscience

Results from public dialogue project shared

Report available


Babraham Institute welcomes new group leader, Rahul Roychoudhuri

Rahul joins Institute’s lymphocyte signalling and development programme

Research focuses on role of transcription factors in T cell…


Research Impact

Industrial Research Collaborations - 19

CASE PhD Studentships - 5

Formal Industrial Consultancy Agreements - 4

Group Leaders