Postdoctoral Research Scientist
We are seeking a Postdoctoral Research Scientist to join the Houseley laboratory. This position is funded through a Wellcome Trust award aimed at discovering the mechanisms by which useful, adaptive mutations such as copy number variation (CNV) form within complex genomes.
The successful candidate will use replicatively aged cohorts of budding yeast to quantify copy number variation (CNV) events in different environments, analysing individual cells by PFGE-southern blot. Particular attention will be given to the development of assays allowing measurement of de novo CNV frequency from single copy loci. Genetic methods will then be used to elucidate the mechanisms by which gene expression alters recombination rate.
The job will also involve a component of mammalian cell culture and analysis to aid ongoing work to translate our findings in yeast to humans. These studies lie at the interface of recombination, chromatin and gene expression, and will require a high level of proficiency in yeast handling and molecular biology.
The successful candidate must have a PhD in Molecular Biology and experience in design and implementation of novel statistical methods.
Funding for this position is available for up to one year.
Full details of the position can be found here.
Starting salary is £30,751 per annum
On applying please quote reference CNV-JH-LTC.
Closing date for completed applications is Monday 26th March 2018.
NO AGENCIES PLEASE
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Job description, Person Specification and Benefits Statement