Life Sciences Research for Lifelong Health
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The latest version of the programme can be downloaded here (times and order are subject to change). 



Monday 27 March 2017

08:30 Registration
08:50 Opening Remarks
Prof. Michael Wakelam, Babraham Institute
09:00 Plenary; New discoveries about ageing in C.elegans
Prof. David Gems, Institute of Healthy Ageing, University College London


Session 1: The Ageing Stem Cell

Chair: Dr. Elisa Laurenti, Wellcome Trust - MRC Cambridge Stem Cell Institute
09:45 Epigenetic stress response and stem cell aging
Dr. Karl Lenhard Rudolph, Leibniz Institute on Aging (FLI)
10:15 DNA methyltransferase 3A in hematopoiesis
Prof. Margaret (Peggy) Goodell, Baylor College of Medicine
10:45 Coffee Break
11:15 Novel epigenetic biomarker and its clinical utility in diagnostics of Alzheimer's disease
Dr. Victoria V. Lunyak, Aelan Cell Technologies
11:45 Autophagy and metabolism of aged hematopoietic stem cells
Dr. Emmanuelle Passegué, UCSF School of Medicine
12:15 Singe cell sequencing reveals age-dependent emergence of pre-malignant haematopoietic stem cells
Dr. Kristina Kirschner, Institute of Cancer Sciences, University of Glasgow - Selected Short Talk
12:30 Impaired immunoglobin repertoire and epigenetic alterations in ageing B cell development
Dr. Anne Corcoran, Babraham Institute
13:00 Lunch

Session 2: The Ageing Immune System

Chair: Prof. Janet Lord, Institute of Inflammation and Ageing, University of Birmingham
14:15 The epigenetic landscape of CD8 T cells in differentiation and ageing
Prof. Jörg J. Goronzy, Stanford School of Medicine
14:45 A global MAPK activation complex coordinated by Sestrins inhibits immunity during ageing
Prof. Arne Akbar, Windeyer Institute, University College London
15:15 Ageing and the germinal centre response
Dr. Michelle Linterman, Babraham Institute
15:45 Afternoon Tea
16:15 Age-Related Functional Defects in Naïve CD8 T Cells Due to Defective TCR Signaling and Inhibition of Cell Cycle
Dr. Kylie Quinn, Monash University - Selected Short Talk
16:30 Mechanisms for inflammation and obesity reducing B cell function in the elderly and old mice
Dr. Bonnie Blomberg, University of Miami Miller School of Medicine
17:00 mTOR inhibition improves immune function in the elderly
Dr. Joan Mannick, Novartis
17:30 Poster Session
19:30 Conference Dinner


Tuesday 28 March 2017


Session 3: Signalling and the Ageing Cell

Chair: Prof. Michael Wakelam, Babraham Institute
09:00 Plenary; Nutrition and ageing
Prof. Dame Linda Partridge, Institute of Healthy Ageing, University College London
09:45 Robust and reproducible chemical interventions in ageing
Dr. Mark Lucanic, Buck Institute for Research on Ageing
10:15 The SKN-1 transcription factor can protect against oxidative damage and increase lifespan in C. elegans by distinct mechanisms
Dr. Jennifer Tullet, School of Biosciences, University of Kent - Selected Short Talk
10:30 Coffee Break
11:00 Signalling pathways during cell senescence and upon senescence reversal by mTOR inhibition revealed by proteomics analysis
Prof. Lynne Cox, University of Oxford - Selected Short Talk
11:15 Correcting signaling dysregulation in neutrophils and improving immunity in older adults
Prof. Janet Lord, Institute of Inflammation and Ageing, University of Birmingham
11:45 Dynamics of autophagy starting from mTOR
Dr. Nick Ktistakis, Babraham Institute
12:15 Lunch


Session 4: Epigenetics of the Ageing Cell

Chair: Dr Olivia Casanueva and Dr Len Stephens, Babraham Institute
13:30 Genetic studies of the epigenetic clock
Prof. Steve Horvath, University of California, Los Angeles
14:00 Convergent mechanisms of longevity
Prof. Adam Antebi, Max Planck Institute for Biology of Ageing
14:30 Plenary; Regulation of Growth by the mTOR Pathway
Prof. David Sabatini, Whitehead Institute, Massachusetts Institute of Technology
15:15 Afternoon Tea
15:45 Mouse epigenetic age and prediction
Mr. Thomas Stubbs, Babraham Institute - Selected Short Talk
16:00 It’s not all down to the egg: Maternal age effects on development and reproductive success
Dr Myriam Hemberger, Babraham Institute
16:30 Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP)
Prof. Jesús Gil, Imperial College London
17:00 Closing remarks
17:15 Depart


Organising Committee

Michael Wakelam Institute Director
Simon Cook Signalling Group Leader
Michelle Linterman Lymphocyte Signalling and Development Group Leader
Patrick Varga-Weisz Nuclear Dynamics Group Leader
Peter Rugg-Gunn Epigenetics Group Leader
Linden Fradet Knowledge Exchange Manager
Tacita Nye Public Engagement Manager