Bhupinder VirkI studied at University College London (UCL) for a B.Sc. in Genetics. It was then that my love for C. elegans and my interest in the field of ageing began - it intrigued me that something so tiny could potentially answer such big questions about ageing and health. After getting my Master’s degree at Imperial College London, I moved “oop north”, to Durham University for my PhD. I used the C. elegans: E. coli (host/microbe) model to look at interactions between host and gut bacteria – focussing on how particular metabolites might influence health and ageing.
After my PhD, I went to Shanghai Jiao Tong University to set up a fully functioning C. elegans facility, as part of a collaboration project. Five months of continuous tropical monsoons and power-cuts later, I was happy to come back to the UK, for a position developing training material in the Bioinformatics group at the Babraham Institute.
Bioinformatics is pretty cool, but I missed the worms! I’m excited to have joined the Casanueva lab as a postdoc, to investigate the mechanisms underlying the widespread rewiring of proteostasis networks during early phases of the ageing process. When I’m not “worming”, I enjoy movies, theatre, live music and fitness classes.
Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
White MA, Kim E, Duffy A
White MA, Kim E, Duffy A
Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.
Olova N, Krueger F, Andrews S
19 1474-760X:33 (2018)
Hanna CW, Taudt A, Huang J
Nature structural & molecular biology
25 1545-9985:73-82 (2018)
Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.
Matheson LS, Bolland DJ, Chovanec P
Frontiers in immunology
8 1664-3224:1550 (2017)
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.
Berrens RV, Andrews S, Spensberger D
Cell stem cell
21 1875-9777:694-703.e7 (2017)
Gahurova L, Tomizawa SI, Smallwood SA
Epigenetics & chromatin
10 1756-8935:25 (2017)
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.
Hahn O, Grönke S, Stubbs TM
18 1474-760X:56 (2017)
Milagre I, Stubbs TM, King MR
18 2211-1247:1079-1089 (2017)
DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids.
Canovas S, Ivanova E, Romar R
6 2050-084X: (2017)
Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells.
Collinson A, Collier AJ, Morgan NP
17 2211-1247:2700-2714 (2016)
Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.
von Meyenn F, Berrens RV, Andrews S
39 1878-1551:104-115 (2016)