David Posner

I grew up in Morelia, a fairly large city in central-west Mexico. In 2012 I moved to the San Francisco Bay in California, where I began my career in biomedical research. I got the wonderful opportunity to spend a few summers working in the lab of Noelle L'Etoile at UCSF studying the role of argonaute protein HRDE-1 in the olfactory adaptation of C. elegans progeny. After my second year of college, I was a fellow in an MD-PhD summer program at Dartmouth College, where I enjoyed a fantastic experience working in David Leib's lab investigating the infiltration of IgG into the Trigeminal Ganglion during a Herpes Simplex Virus infection, where I was a co-author.

I graduated with a bachelor's in Biochemistry from Siena College, about 3 hours north of Manhattan, but I worked in a natural products chemistry lab. Alongside my mentor, Stephen Deyrup, I developed assays to study antibiotic production from live fungi. Other projects in the lab included the identification of chemical defence molecules called lucibufagins in several species of fireflies using 2D NMR techniques, HPLC and LCMS.

Now, I have the pleasure of being in Adrian Liston's lab where I am working toward my PhD. I currently study a special subset of regulatory T cells (Treg) that are found in the brain. Normally, Tregs are heavily involved in immunosuppression of effector T cells in order to prevent autoimmune disease. Recently, a lot of the efforts in the field have been focused on describing the specialized function of Tregs in various tissues such as the skin, the gut, lungs and muscle (to name a few). In our lab, we are hoping to elucidate the function of brain Tregs during development, and how they help maintain, or fail to do so, in homeostasis and disease.