Life Sciences Research for Lifelong Health

Richard Odle

Richard grew up in Medway and found the prospect of excessive coffee consumption a suitable incentive for studying medicine at Cambridge. He is now undertaking an MB/PhD to spend some time researching with the Cookies. During his undergraduate degree, he developed an interest in cancer research and his third year project with Professor Nick Coleman investigated the signalling networks of the Human Papilloma Virus oncoproteins E6/E7. He has also researched, with Dr Gary Doherty, clinical prognostic indicators in ovarian cancer patients.

His current research focuses on the regulation of Transcription Factor EB (TFEB), in relation to ERK1/2 and the cell cycle. In his spare time, he enjoys attempting (but ultimately failing) to learn Mandarin and cooking (which tends to go wrong as well).

Richard is the first medic to undertake a PhD in the Cook lab and has taken responsibility for our health and wellbeing. He is always on hand with a warm stethoscope, suitable analgesia and an excellent bedside manner.
 

Latest Publications

Control of cell death and mitochondrial fission by ERK1/2 MAP Kinase signalling.

Cook SJ, Stuart K, Gilley R

The FEBS journal
1742-4658: (2017)

PMID: 28548464

Visualisation of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R

Bioconjugate chemistry
1520-4812: (2017)

PMID: 28449575

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S

Science (New York, N.Y.)
352 1095-9203:453-9 (2016)

PMID: 27102483

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ

Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)

PMID: 26959608

Maternal DNA Methylation Regulates Early Trophoblast Development.

Branco MR, King M, Perez-Garcia V

Developmental cell
36 1878-1551:152-63 (2016)

PMID: 26812015

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

Caunt CJ, Sale MJ, Smith PD

Nature reviews. Cancer
15 1474-1768:577-92 (2015)

PMID: 26399658

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M

Cellular and molecular life sciences : CMLS
1420-9071: (2015)

PMID: 26346493