Life Sciences Research for Lifelong Health

Emma Minihane

Emma grew up on the island of Jersey and went on to study Molecular & Cellular Biology at the University of Bath. Her interest in signalling sparked from a research project she undertook with Dr Jim Caunt, studying ERK1/2 and PKB responses to nerve growth factor in the PC12 model system.
 
After a 5-month stint travelling in the USA (visiting 23/50 States), Emma re-entered the world of science and joined the Cook lab in 2016. Her work is in collaboration with AstraZeneca, focusing on combining BH3 mimetics with kinase inhibitors in cancer.
 
Still an islander at heart, Emma enjoys many water sports and misses being by the sea. She is a jazz drummer (yes really!) and is also currently teaching herself how to play the guitar (very badly). 

Note from Editor.
It is unclear from Emma’s account if she is very bad at teaching herself or very bad at playing the guitar. No doubt such ambiguity in writing will be sorted by the time she comes to write her thesis.


Latest Publications

Control of cell death and mitochondrial fission by ERK1/2 MAP Kinase signalling.

Cook SJ, Stuart K, Gilley R

The FEBS journal
1742-4658: (2017)

PMID: 28548464

Visualisation of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R

Bioconjugate chemistry
1520-4812: (2017)

PMID: 28449575

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S

Science (New York, N.Y.)
352 1095-9203:453-9 (2016)

PMID: 27102483

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ

Cell cycle (Georgetown, Tex.)
15 1551-4005:506-18 (2016)

PMID: 26959608

Maternal DNA Methylation Regulates Early Trophoblast Development.

Branco MR, King M, Perez-Garcia V

Developmental cell
36 1878-1551:152-63 (2016)

PMID: 26812015

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

Caunt CJ, Sale MJ, Smith PD

Nature reviews. Cancer
15 1474-1768:577-92 (2015)

PMID: 26399658

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M

Cellular and molecular life sciences : CMLS
1420-9071: (2015)

PMID: 26346493