Life Sciences Research for Lifelong Health

Rahul Samant

Our current focus is on the use of drugs targeting the molecular chaperone HSP90—a key regulator of proteostasis—to investigate the plasticity of protein clearance pathways in young, aged, and diseased cells.

01223 496492

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Latest Publications

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy.

Samant RS, Masto VB, Frydman J

Genes & development
33 1549-5477:1027-1030 (2019)

PMID: 31371460

Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae.

Samant RS, Frydman J

Methods in enzymology
619 1557-7988:27-45 (2019)

PMID: 30910025

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control.

Samant RS, Livingston CM, Sontag EM

Nature
563 1476-4687:407-411 (2018)

PMID: 30429547

Mechanisms and Functions of Spatial Protein Quality Control.

Sontag EM, Samant RS, Frydman J

Annual review of biochemistry
86 1545-4509:97-122 (2017)

PMID: 28489421

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Dale T, Clarke PA, Esdar C

Nature chemical biology
11 1552-4469:973-980 (2015)

PMID: 26502155

E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.

Samant RS, Clarke PA, Workman P

Proceedings of the National Academy of Sciences of the United States of America
111 1091-6490:6834-9 (2014)

PMID: 24760825

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

Polier S, Samant RS, Clarke PA

Nature chemical biology
9 1552-4469:307-12 (2013)

PMID: 23502424

Molecular biology: Choose your protein partners.

Samant RS, Workman P

Nature
490 1476-4687:351-2 (2012)

PMID: 23075983

The expanding proteome of the molecular chaperone HSP90.

Samant RS, Clarke PA, Workman P

Cell cycle (Georgetown, Tex.)
11 1551-4005:1301-8 (2012)

PMID: 22421145