Life Sciences Research for Lifelong Health
Len Stephens' and Phill Hawkins' research group

Karen Anderson

Karen did her PhD in Biochemistry at the Baker Medical Research Institute/Melbourne University in Australia investigating phosphatidylinositol signalling in myocardial ischaemia and reperfusion. She came to the Inositide laboratory in 1997 as part of a two year Australian NHMRC CJ Martin/RG Menzies fellowship, and remained in the lab for a further three years after being awarded a Beit Memorial Postdoctoral Fellowship. She returned to Melbourne, Australia in 2001 to complete her CJ Martin, and then subsequently a RD Wright Fellowship. Karen returned to the Inositide lab in 2004, and became a Babraham Institute Senior Research Associate in 2005. Currently, she is investigating the molecular mechanisms regulating the activation of PI3Kβ.

Latest Publications

The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P.

Furlong RM, Lindsay A, Anderson KE

Journal of cell science
1477-9137: (2019)

PMID: 31540955

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T

Proceedings of the National Academy of Sciences of the United States of America
115 1091-6490:12176-12181 (2018)

PMID: 30442661

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J

Biochimica et biophysica acta
0006-3002: (2018)

PMID: 29902570

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ

Blood advances
1 2473-9529:918-932 (2017)

PMID: 29242851

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T

Molecular cell
1097-4164: (2017)

PMID: 29056325

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT

Cancers
9 : (2017)

PMID: 28273837

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR

Journal of immunology (Baltimore, Md. : 1950)
198 1550-6606:1285-1296 (2017)

PMID: 28039302

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27601656