Life Sciences Research for Lifelong Health
Len Stephens' and Phill Hawkins' research group

Phillip Hawkins

Phillip Hawkins shares responsibility with Len Stephens for running an academic research laboratory aimed at understanding the physiological function of phosphoinositide 3-kinase (PI3K) signaling pathways. Most of his early work concerned the structures of the lipid messengers generated by this pathway and the molecular mechanisms by which they act as intracellular signals. This work contributed to the greater body of knowledge which has now established PI3K signaling pathways as complex regulatory webs controlling cell surface receptor signaling and intracellular vesicle trafficking, and hence several important cell responses, such as cell growth, survival, autophagy and movement. In recent years, his laboratory has focused on the role of Class I and III PI3Ks in the regulation of neutrophil chemokinesis and the oxidative burst. As this field has matured, several therapeutic opportunities have arisen for targeting this pathway and he acts as a consultant for several pharmaceutical companies who are attempting to create novel drugs in this area.

1985-1987 Postdoctoral Fellow, S.K. & F. Research Ltd, Welwyn, UK
1987-1988 Postdoctoral Fellow, Molecular Neurobiology Unit, MRC Centre, Cambridge, UK
1988-1990 Lister Fellow, Molecular Neurobiology Unit, MRC Centre, Cambridge, UK
1990-1993 Lister Fellow, AFRC IAPGR, The Babraham Institute, Cambridge, UK
1993-1998 BBSRC Senior Research Fellow, The Babraham Institute, Cambridge, UK
1998-2003 BBSRC Advanced Fellow, The Babraham Institute, Cambridge, UK
2003- Group Leader, The Babraham Institute, Cambridge, UK

01223 496598

Email Phillip

Latest Publications

The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P.

Furlong RM, Lindsay A, Anderson KE

Journal of cell science
1477-9137: (2019)

PMID: 31540955

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T

Proceedings of the National Academy of Sciences of the United States of America
115 1091-6490:12176-12181 (2018)

PMID: 30442661

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J

Biochimica et biophysica acta
0006-3002: (2018)

PMID: 29902570

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ

Blood advances
1 2473-9529:918-932 (2017)

PMID: 29242851

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T

Molecular cell
1097-4164: (2017)

PMID: 29056325

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT

Cancers
9 : (2017)

PMID: 28273837

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR

Journal of immunology (Baltimore, Md. : 1950)
198 1550-6606:1285-1296 (2017)

PMID: 28039302

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27601656