Simon RudgeSimon studied for his BSc Hons in Biochemistry at the University of Bristol. After completing his PhD in Biochemistry at the University of Birmingham, he took up post-doctoral positions in the USA. During this time, Simon started working on phospholipase D-mediated signalling in the yeast Sacchromyces cerevisae, and this work resulted in the cloning and characterisation of PLD1 and PLD2. Simon returned to the UK to join Professor Wakelam’s laboratory and continue his research on PLD enzymes. Simon regularly mentors visiting summer students in the lab, and has recently participated in the Institute’s collaboration with the newly opened University Technical College Cambridge. He enjoys being an active member of the Athena Swan and public engagement committees.
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.
Hahn O, Grönke S, Stubbs TM
18 1474-760X:56 (2017)
Farquhar MJ, Humphreys IS, Rudge SA
Journal of hepatology
Kilbey A, Terry A, Wotton S
Journal of cellular biochemistry
118 1097-4644:1432-1441 (2017)
Thakur R, Panda A, Coessens E
5 2050-084X: (2016)
Nguyen A, Rudge SA, Zhang Q
Current opinion in biotechnology
43 1879-0429:96-103 (2017)
Huang-Doran I, Tomlinson P, Payne F
1 :e88766 (2016)
The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.
Vermeren MM, Zhang Q, Smethurst E
11 1932-6203:e0162814 (0)
Exosomes bind autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells.
Jethwa SA, Leah EJ, Zhang Q
Journal of cell science
Cader MZ, Boroviak K, Zhang Q
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Peck B, Schug ZT, Zhang Q
Cancer & metabolism
4 2049-3002:6 (2016)
Morales-Rios E, Watt IN, Zhang Q
5 2046-2441: (2015)
Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.
Sanchez-Alvarez M, Zhang Q, Finger F
5 2046-2441: (2015)