Life Sciences Research for Lifelong Health
Sharpe Lab 2019

Iain Hay

Originally from the Kingdom of Scotland, Iain completed a BSc in Molecular & Cellular Biology at the University of Glasgow. Heading south in search of warmer climes, Iain joined the 4-year PhD programme at the Cambridge Institute for Medical Research. After 3 rotation projects which earned him an MRes in Medical Science, he elected to stay in the Sharpe Lab to complete his PhD project.

His work focuses on using structural and biochemical techniques to investigate the mechanism of tyrosine phosphatase activity; with a particular focus on those which harbour non-canonical enzymatic motifs.

Outside of work, Iain can be found rowing on the Cam or playing guitar in Cambridge’s most mediocre cover band.

Latest Publications

Vismodegib resistant mutations are not selected in multifocal relapses of locally advanced basal cell carcinoma after vismodegib discontinuation.

Ighilahriz M, Benfodda M, Sharpe H

Journal of the European Academy of Dermatology and Venereology : JEADV
1468-3083: (2019)

PMID: 31187903

Grking the Smoothened signal.

Sharpe HJ, de Sauvage FJ

Science signaling
11 1937-9145: (2018)

PMID: 29438011

A new trick for an old lipid.

Sharpe H

5 2050-084X: (2016)

PMID: 27885984

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.

Bonilla X, Parmentier L, King B

Nature genetics
48 1546-1718:398-406 (2016)

PMID: 26950094

Regulation of the oncoprotein Smoothened by small molecules.

Sharpe HJ, Wang W, Hannoush RN

Nature chemical biology
11 1552-4469:246-55 (2015)

PMID: 25785427

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.

Sharpe HJ, Pau G, Dijkgraaf GJ

Cancer cell
27 1878-3686:327-41 (2015)

PMID: 25759019

Efficacy of Hedgehog pathway inhibitors in Basal cell carcinoma.

Basset-Seguin N, Sharpe HJ, de Sauvage FJ

Molecular cancer therapeutics
14 1538-8514:633-41 (2015)

PMID: 25585509

Signaling: An oxysterol ligand for Smoothened.

Sharpe HJ, de Sauvage FJ

Nature chemical biology
8 1552-4469:139-40 (2012)

PMID: 22257852

A comprehensive comparison of transmembrane domains reveals organelle-specific properties.

Sharpe HJ, Stevens TJ, Munro S

142 1097-4172:158-69 (2010)

PMID: 20603021

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.

Strisovsky K, Sharpe HJ, Freeman M

Molecular cell
36 1097-4164:1048-59 (2009)

PMID: 20064469