ResearchIncreasing evidence suggests that the three dimensional, spatial organisation of the genome in the interphase nucleus plays a fundamental role in regulating genome function. At the highest level, individual chromosomes are tissue-specifically arranged in interphase such that frequent juxtaposition of ‘preferred neighbour’ chromosomes occurs, suggesting a role in cell-type specific gene expression patterns.
Some of our past and present research areas:
Promoter Capture Hi-C
Cell-to-cell variability in chromosome structure
Preferential associations between co-regulated genes
Non-coding RNA and epigenetic silencing of gene expression
Long range chromatin interactions