Life Sciences Research for Lifelong Health

Group Members

Dr Peter Fraser

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Mr Stephen Bevan

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Dr Jonathan Cairns

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Mr Andrew Dimond

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Dr Biola Javierre

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Dr Hashem Koohy

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Dr Wing Leung

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Dr Valeriya Malysheva

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Mr Marco Michalski

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Dr Jorg Morf

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Clare Murnane

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Dr Takashi Nagano

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Dr Stefan Schoenfelder

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Dr Sven Sewitz

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Dr Csilla Varnai

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Dr Steven Wingett

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Latest Publications

Capturing Three-Dimensional Genome Organization in Individual Cells by Single-Cell Hi-C.

Nagano T, Wingett SW, Fraser P

Methods in molecular biology (Clifton, N.J.)
1654 1940-6029:79-97 (2017)

PMID: 28986784

Chromosome contacts in activated T cells identify autoimmune disease candidate genes.

Burren OS, Rubio García A, Javierre BM

Genome biology
18 1474-760X:165 (2017)

PMID: 28870212

Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.

Rubin AJ, Barajas BC, Furlan-Magaril M

Nature genetics
1546-1718: (2017)

PMID: 28805829

Platelet function is modified by common sequence variation in megakaryocyte super enhancers.

Petersen R, Lambourne JJ, Javierre BM

Nature communications
8 2041-1723:16058 (2017)

PMID: 28703137

Cell-cycle dynamics of chromosomal organization at single-cell resolution.

Nagano T, Lubling Y, Várnai C

Nature
547 1476-4687:61-67 (2017)

PMID: 28682332

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation.

Siersbæk R, Madsen JGS, Javierre BM

Molecular cell
66 1097-4164:420-435.e5 (2017)

PMID: 28475875

GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.

Mifsud B, Martincorena I, Darbo E

PloS one
12 1932-6203:e0174744 (2017)

PMID: 28379994

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Freire-Pritchett P, Schoenfelder S, Várnai C

eLife
6 2050-084X: (2017)

PMID: 28332981

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.

Aymard F, Aguirrebengoa M, Guillou E

Nature structural & molecular biology
1545-9985: (2017)

PMID: 28263325

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.

Javierre BM, Burren OS, Wilder SP

Cell
167 1097-4172:1369-1384.e19 (2016)

PMID: 27863249