Life Sciences Research for Lifelong Health
Roychoudhuri Group members

Rahul Roychoudhuri

Rahul’s research focuses on understanding how transcription factors guide the differentiation and function of immune cells called T lymphocytes. Rahul’s group applies diverse approaches in molecular biology, cellular immunology and functional genomics to investigate how lymphocyte behaviour is controlled in the context of infections, autoimmunity and cancer. His research aims to identify targets for a new class of therapies that will powerfully manipulate immune function in patients with autoimmunity, chronic infection and cancer.

Rahul studied Natural Sciences at the University of Cambridge before training in Clinical Medicine at King's College London. His early post-doctoral work in Gary Nabel’s laboratory at the US National Institute of Allergy and Infectious Diseases explored heterogeneity in transcription factor expression at the single-cell level during immune responses to infection. His later work in Nick Restifo’s lab at the National Cancer Institute explored the function of key transcription factors in guiding lymphocyte differentiation. This work established the central role of a basic leucine-zipper transcription factor BACH2 in maintenance of immunological tolerance.

His current work focuses on how T-cell fate decisions are controlled by external stimuli, how transcription factors collaborate and compete with each other to achieve contextual regulation of gene expression and cellular differentiation and how polymorphisms in regulatory elements make humans susceptible to immune-mediated disease.

Latest Publications

Genome-Wide Measurement and Computational Analysis of Transcription Factor Binding and Chromatin Accessibility in Lymphocytes.

Sadiyah MF, Roychoudhuri R

Current protocols in immunology
126 1934-368X:e84 (2019)

PMID: 31483104

Regulatory T cells in cancer: where are we now?

Gallimore A, Quezada SA, Roychoudhuri R

Immunology
157 1365-2567:187-189 (2019)

PMID: 31225653

Regulation of regulatory T cells in cancer.

Stockis J, Roychoudhuri R, Halim TYF

Immunology
1365-2567: (2019)

PMID: 31032905

T cell stemness and dysfunction in tumors are triggered by a common mechanism.

Vodnala SK, Eil R, Kishton RJ

Science (New York, N.Y.)
363 1095-9203: (2019)

PMID: 30923193

The transcription factor c-Myb regulates CD8 T cell stemness and antitumor immunity.

Gautam S, Fioravanti J, Zhu W

Nature immunology
20 1529-2916:337-349 (2019)

PMID: 30778251

Paths to expansion: Differential requirements of IRF4 in CD8 T-cell expansion driven by antigen and homeostatic cytokines.

Lugli E, Brummelman J, Pilipow K

European journal of immunology
48 1521-4141:1281-1284 (2018)

PMID: 30133745

Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors.

Miura Y, Morooka M, Sax N

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2018)

PMID: 29540581

Epigenetic control of CD8+ T cell differentiation.

Henning AN, Roychoudhuri R, Restifo NP

Nature reviews. Immunology
1474-1741: (2018)

PMID: 29379213

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J

Nature immunology
1529-2916: (2017)

PMID: 28530713

BACH transcription factors in innate and adaptive immunity.

Igarashi K, Kurosaki T, Roychoudhuri R

Nature reviews. Immunology
1474-1741: (2017)

PMID: 28461702