Life Sciences Research for Lifelong Health

Carly Whyte

I’m a cellular immunologist and am interested in understanding the mechanisms that underlie the balance between immune activation and tolerance. I completed my PhD in 2018 at the University of Adelaide, Australia, where I worked on understanding how the migration of T cells is regulated through distinct chemokine receptor axes in tumors and infectious models. Upon joining the Liston lab, I’ve been working to understand how IL-2 influences different aspects of the immune system, and how we can manipulate expression of this cytokine to improve therapeutic outcomes.

Latest Publications

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Habets RA, de Bock CE, Serneels L

Science translational medicine
11 1946-6242: (2019)

PMID: 31142678

Inborn errors of immunity: single mutations unravel mechanisms of immune disease.

Liston A, Humblet-Baron S

Immunology and cell biology
1440-1711: (2019)

PMID: 30942931

The Aire family expands.

Liston A, Dooley J

The Journal of experimental medicine
1540-9538: (2019)

PMID: 30923044

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.

Van Nieuwenhove E, Lagou V, Van Eyck L

Annals of the rheumatic diseases
1468-2060: (2019)

PMID: 30862608

Prospective study evaluating immune-mediated mechanisms and predisposing factors underlying persistent postinfectious abdominal complaints.

Florens MV, Van Wanrooy S, Dooley J

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
31 1365-2982:e13542 (2019)

PMID: 30657233

IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis.

Humblet-Baron S, Franckaert D, Dooley J

The Journal of allergy and clinical immunology
1097-6825: (2018)

PMID: 30578871

NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology.

Schlenner S, Pasciuto E, Lagou V

Annals of the rheumatic diseases
78 1468-2060:342-349 (2019)

PMID: 30552177

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V, Garcia-Perez JE, Smets I

Cell reports
25 2211-1247:798-810.e6 (2018)

PMID: 30332657

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.

van Nieuwenhuijze A, Burton O, Lemaitre P

Frontiers in immunology
9 1664-3224:2234 (2018)

PMID: 30323813

The Long Non-coding RNA Anticipates Foxp3 Expression in Regulatory T Cells.

Brajic A, Franckaert D, Burton O

Frontiers in immunology
9 1664-3224:1989 (2018)

PMID: 30319599