Thomas Stubbs2014 - present – PhD candidate in Molecular Biology, Babraham Institute, Cambridge, UK (under the supervision of Professor Wolf Reik).
2013-2014 – Master’s degree in Research (MRes), University of Cambridge, UK.
2009-2013 – Master’s degree in Molecular and Cellular Biochemistry (MBiochem), University of Oxford, UK (First-class honours).
My research interest is centered on the most prolific of all diseases: ageing. Why do organisms age? What does ageing mean at a cellular and molecular level? In particular, I am interested in the epigenetic changes that characterise ageing and how these changes can be used not only to study but also to halt or reverse aspects of ageing. My research is focused on understanding the dynamics of DNA methylation with age and how we can use these dynamics to predict biological age in the mouse. This readout of biological age in the mouse will aid the speed with which ageing can be studied in mammalian systems.
Vasiliauskaitė L, Berrens RV, Ivanova I
Nature structural & molecular biology
25 1545-9985:394-404 (2018)
Eckersley-Maslin MA, Alda-Catalinas C, Reik W
Nature reviews. Molecular cell biology
Guo G, von Meyenn F, Rostovskaya M
Development (Cambridge, England)
145 1477-9129: (2018)
Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.
Olova N, Krueger F, Andrews S
19 1474-760X:33 (2018)
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
Clark SJ, Argelaguet R, Kapourani CA
9 2041-1723:781 (2018)
Regev A, Teichmann SA, Lander ES
6 2050-084X: (2017)
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
Aarts M, Georgilis A, Beniazza M
Genes & development
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.
Berrens RV, Andrews S, Spensberger D
Cell stem cell
21 1875-9777:694-703.e7 (2017)
Martin-Herranz DE, Ribeiro AJM, Krueger F
Nucleic acids research
Yang J, Ryan DJ, Wang W
Kelsey G, Stegle O, Reik W
Science (New York, N.Y.)
358 1095-9203:69-75 (2017)
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.
Mohammed H, Hernando-Herraez I, Savino A
20 2211-1247:1215-1228 (2017)