Rebecca BerrensShort Biography
2013 - current: PhD student at Cambridge University, Babraham Institute (Funded by Gates Cambridge scholarship)
2010 - 2012: Master in Molecular Biotechnology at Heidelberg University
2007 - 2010: Bachelor in Molecular Cell Biology at Heidelberg University
Research Interests and Activities
I am interested in transposon regulation and its role in epigenetic reprogramming during early embryonic development in mammals.
Transposons are known to be highly guarded by DNA methylation in somatic cells, though histone modifications and small RNAs have also been found to play a role in keeping these repeat elements in check.
My work focuses on the effect of the genome wide erasure of epigenetic marks in the early embryo, on transposon activity. Specifically, the dynamics and interplay between DNA methylation, histone modifications and, my main area of interest- small RNAs, which lead to the silencing of transposons.
Vasiliauskaitė L, Berrens RV, Ivanova I
Nature structural & molecular biology
25 1545-9985:394-404 (2018)
Eckersley-Maslin MA, Alda-Catalinas C, Reik W
Nature reviews. Molecular cell biology
Guo G, von Meyenn F, Rostovskaya M
Development (Cambridge, England)
145 1477-9129: (2018)
Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.
Olova N, Krueger F, Andrews S
19 1474-760X:33 (2018)
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
Clark SJ, Argelaguet R, Kapourani CA
9 2041-1723:781 (2018)
Regev A, Teichmann SA, Lander ES
6 2050-084X: (2017)
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
Aarts M, Georgilis A, Beniazza M
Genes & development
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.
Berrens RV, Andrews S, Spensberger D
Cell stem cell
21 1875-9777:694-703.e7 (2017)
Martin-Herranz DE, Ribeiro AJM, Krueger F
Nucleic acids research
Yang J, Ryan DJ, Wang W
Kelsey G, Stegle O, Reik W
Science (New York, N.Y.)
358 1095-9203:69-75 (2017)
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.
Mohammed H, Hernando-Herraez I, Savino A
20 2211-1247:1215-1228 (2017)