Christel KruegerShort biography
- 2005 - current: Post-Doctoral Research Associate, Babraham Institute, Cambridge, UK (funded by personal fellowships from EMBO, DFG and CTR, as well as by BBSRC and Wellcome Trust grants)
- 2001 - 2004: PhD in Biology, Friedrich-Alexander Universitaet Erlangen, Germany (State of Bavaria Fellowship)
Research Interests and Activities
I have a fascination with life, especially with the beginning of it. When the parental gametes meet to form a zygote, a new organism comes into being. A number of biologically drastic measures are taken both before and after fertilisation to turn the old generation into a new one: Not only is the age of the parental cells set to zero, but also are two highly specialised cells (the gametes) turned into one all-rounder (the totipotent zygote). Being a molecular biologist, I’m interested in how this is brought about on a molecular level, and currently I’m studying a potential mechanism of bringing about totipotency.
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.
Berrens RV, Andrews S, Spensberger D
Cell stem cell
21 1875-9777:694-703.e7 (2017)
Martin-Herranz DE, Ribeiro AJM, Krueger F
Nucleic acids research
Yang J, Ryan DJ, Wang W
Kelsey G, Stegle O, Reik W
Science (New York, N.Y.)
358 1095-9203:69-75 (2017)
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.
Mohammed H, Hernando-Herraez I, Savino A
20 2211-1247:1215-1228 (2017)
Guo G, von Meyenn F, Rostovskaya M
Development (Cambridge, England)
144 1477-9129:2748-2763 (2017)
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.
Kirschner K, Chandra T, Kiselev V
19 2211-1247:1503-1511 (2017)
Vasiliauskaitė L, Vitsios D, Berrens RV
Nature structural & molecular biology
Stubbs TM, Bonder MJ, Stark AK
18 1474-760X:68 (2017)
Angermueller C, Lee HJ, Reik W
18 1474-760X:67 (2017)
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.
Hahn O, Grönke S, Stubbs TM
18 1474-760X:56 (2017)
Kiselev VY, Kirschner K, Schaub MT