Christel KruegerShort biography
- 2005 - current: Post-Doctoral Research Associate, Babraham Institute, Cambridge, UK (funded by personal fellowships from EMBO, DFG and CTR, as well as by BBSRC and Wellcome Trust grants)
- 2001 - 2004: PhD in Biology, Friedrich-Alexander Universitaet Erlangen, Germany (State of Bavaria Fellowship)
Research Interests and Activities
I have a fascination with life, especially with the beginning of it. When the parental gametes meet to form a zygote, a new organism comes into being. A number of biologically drastic measures are taken both before and after fertilisation to turn the old generation into a new one: Not only is the age of the parental cells set to zero, but also are two highly specialised cells (the gametes) turned into one all-rounder (the totipotent zygote). Being a molecular biologist, I’m interested in how this is brought about on a molecular level, and currently I’m studying a potential mechanism of bringing about totipotency.
Rulands S, Lee HJ, Clark SJ
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
Sun W, Dong H, Becker AS
Vasiliauskaitė L, Berrens RV, Ivanova I
Nature structural & molecular biology
25 1545-9985:394-404 (2018)
Eckersley-Maslin MA, Alda-Catalinas C, Reik W
Nature reviews. Molecular cell biology
Guo G, von Meyenn F, Rostovskaya M
Development (Cambridge, England)
145 1477-9129: (2018)
Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.
Olova N, Krueger F, Andrews S
19 1474-760X:33 (2018)
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
Clark SJ, Argelaguet R, Kapourani CA
9 2041-1723:781 (2018)
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
Aarts M, Georgilis A, Beniazza M
Genes & development
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.
Berrens RV, Andrews S, Spensberger D
Cell stem cell
21 1875-9777:694-703.e7 (2017)
Martin-Herranz DE, Ribeiro AJM, Krueger F
Nucleic acids research
Yang J, Ryan DJ, Wang W