Bhupinder VirkI studied at University College London (UCL) for a B.Sc. in Genetics. It was then that my love for C. elegans and my interest in the field of ageing began - it intrigued me that something so tiny could potentially answer such big questions about ageing and health. After getting my Master’s degree at Imperial College London, I moved “oop north”, to Durham University for my PhD. I used the C. elegans: E. coli (host/microbe) model to look at interactions between host and gut bacteria – focussing on how particular metabolites might influence health and ageing.
After my PhD, I went to Shanghai Jiao Tong University to set up a fully functioning C. elegans facility, as part of a collaboration project. Five months of continuous tropical monsoons and power-cuts later, I was happy to come back to the UK, for a position developing training material in the Bioinformatics group at the Babraham Institute.
Bioinformatics is pretty cool, but I missed the worms! I’m excited to have joined the Casanueva lab as a postdoc, to investigate the mechanisms underlying the widespread rewiring of proteostasis networks during early phases of the ageing process. When I’m not “worming”, I enjoy movies, theatre, live music and fitness classes.
Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism .
Witting M, Hastings J, Rodriguez N
Frontiers in molecular biosciences
5 2296-889X:96 (2018)
Li C, Casanueva O
Essays in biochemistry
60 1744-1358:191-202 (2016)
Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells.
W Lu, MO Casanueva, AP Mahowald
10 7:e1001357 (2012)
MO Casanueva, A Burga, B Lehner
Science (New York, N.Y.)
335 6064:82-5 (2012)
A Burga, MO Casanueva, B Lehner
480 7376:250-3 (2011)
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.
SM Garcia, MO Casanueva, MC Silva
Genes & development
21 22:3006-16 (2007)
Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.
MO Casanueva, EL Ferguson
Development (Cambridge, England)
131 9:1881-90 (2004)
At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ.
OI Casanueva, P Deprez, T García-Huidobro
Biochemical and biophysical research communications
250 2:312-7 (1998)
A major portion of synaptic basal lamina acetylcholinesterase is detached by high salt- and heparin-containing buffers from rat diaphragm muscle and Torpedo electric organ.
Casanueva OI, García-Huidobro T, Campos EO
The Journal of biological chemistry
273 0021-9258:4258-65 (1998)
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
NC Inestrosa, A Alvarez, CA Pérez
16 4:881-91 (1996)