Life Sciences Research for Lifelong Health
Casanueva Group members

Sharlene Murdoch

I was born and raised in Montreal, Canada where I developed a love for hockey (or ice hockey as you call it over here) and maple syrup. I studied at McGill University where I obtained a B. Sc. in Biology and went on to a Master’s in Human Genetics researching the genetic basis of Recurrent Familial Hydatidiform Moles under Dr Rima Slim. After completing this degree I went on to indulge my other loves of travel and teaching in South Korea where I taught English as a Second Language in Seoul. After five years working and having exciting adventures in exotic locales I missed being a scientist and decided to move on to an even more exotic land: Scotland. While studying for another Master’s degree at the University of Aberdeen I developed affection for rugby and Haggis though not so much for Scottish weather. After graduating I got a job as a Research Technician at King’s College London, there I was introduced to our model organism C. elegans. After two years in London I was happy to leave the hustle and bustle and overcrowded tubes to come to Cambridge join the Casanueva lab as a Senior Research Assistant. When not wrangling worms, I enjoy fitness, travel and playing board games. I’m happy to have made England my new home but still really miss hockey and decent maple syrup.

Latest Publications

Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. Elegans Ageing.

Hastings J, Mains A, Virk B

Frontiers in molecular biosciences
6 2296-889X:2 (2019)

PMID: 30788345

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism .

Witting M, Hastings J, Rodriguez N

Frontiers in molecular biosciences
5 2296-889X:96 (2018)

PMID: 30488036

Epigenetic inheritance of proteostasis and ageing.

Li C, Casanueva O

Essays in biochemistry
60 1744-1358:191-202 (2016)

PMID: 27744335

Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans.

MO Casanueva, A Burga, B Lehner

Science (New York, N.Y.)
335 6064:82-5 (2012)

DOI: 10.1126/science.1213491

PMID: 22174126

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.

SM Garcia, MO Casanueva, MC Silva

Genes & development
21 22:3006-16 (2007)

DOI: 10.1101/gad.1575307

PMID: 18006691

Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.

MO Casanueva, EL Ferguson

Development (Cambridge, England)
131 9:1881-90 (2004)

DOI: 10.1242/dev.01076

PMID: 15105369