Life Sciences Research for Lifelong Health
Casanueva Group members

Abraham Mains

Abraham is from that little island in the South Pacific known as Middle Earth. While completing an honours degree at Victoria University of Wellington he became fascinated with the field of aging when confronted by the question; why can a house dog, who shares the same lifestyle and much of their biology with humans, live for only 10-15 years and yet a human can live to 127 (Ms Becerra from Mexico, 1887-present)? In order to explore this question, Abraham travelled 18,389 km to Babraham where he is using the nematode worm, C. elegans, to tease out the molecular basis of lifespan variability with a particular focus on nutrient sensing and stress response pathways. In his 4 minutes of allocated spare time a day he enjoys science fiction films and books, throwing cursed rings into volcanoes, and coffee.

01223 496372

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Latest Publications

Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. Elegans Ageing.

Hastings J, Mains A, Virk B

Frontiers in molecular biosciences
6 2296-889X:2 (2019)

PMID: 30788345

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism .

Witting M, Hastings J, Rodriguez N

Frontiers in molecular biosciences
5 2296-889X:96 (2018)

PMID: 30488036

Epigenetic inheritance of proteostasis and ageing.

Li C, Casanueva O

Essays in biochemistry
60 1744-1358:191-202 (2016)

PMID: 27744335

Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans.

MO Casanueva, A Burga, B Lehner

Science (New York, N.Y.)
335 6064:82-5 (2012)

DOI: 10.1126/science.1213491

PMID: 22174126

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.

SM Garcia, MO Casanueva, MC Silva

Genes & development
21 22:3006-16 (2007)

DOI: 10.1101/gad.1575307

PMID: 18006691

Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.

MO Casanueva, EL Ferguson

Development (Cambridge, England)
131 9:1881-90 (2004)

DOI: 10.1242/dev.01076

PMID: 15105369