Abraham MainsAbraham is from that little island in the South Pacific known as Middle Earth. While completing an honours degree at Victoria University of Wellington he became fascinated with the field of aging when confronted by the question; why can a house dog, who shares the same lifestyle and much of their biology with humans, live for only 10-15 years and yet a human can live to 127 (Ms Becerra from Mexico, 1887-present)? In order to explore this question, Abraham travelled 18,389 km to Babraham where he is using the nematode worm, C. elegans, to tease out the molecular basis of lifespan variability with a particular focus on nutrient sensing and stress response pathways. In his 4 minutes of allocated spare time a day he enjoys science fiction films and books, throwing cursed rings into volcanoes, and coffee.
Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism .
Witting M, Hastings J, Rodriguez N
Frontiers in molecular biosciences
5 2296-889X:96 (2018)
Li C, Casanueva O
Essays in biochemistry
60 1744-1358:191-202 (2016)
Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells.
W Lu, MO Casanueva, AP Mahowald
10 7:e1001357 (2012)
MO Casanueva, A Burga, B Lehner
Science (New York, N.Y.)
335 6064:82-5 (2012)
A Burga, MO Casanueva, B Lehner
480 7376:250-3 (2011)
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.
SM Garcia, MO Casanueva, MC Silva
Genes & development
21 22:3006-16 (2007)
Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.
MO Casanueva, EL Ferguson
Development (Cambridge, England)
131 9:1881-90 (2004)
At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ.
OI Casanueva, P Deprez, T García-Huidobro
Biochemical and biophysical research communications
250 2:312-7 (1998)
A major portion of synaptic basal lamina acetylcholinesterase is detached by high salt- and heparin-containing buffers from rat diaphragm muscle and Torpedo electric organ.
Casanueva OI, García-Huidobro T, Campos EO
The Journal of biological chemistry
273 0021-9258:4258-65 (1998)
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
NC Inestrosa, A Alvarez, CA Pérez
16 4:881-91 (1996)