Life Sciences Research for Lifelong Health
Houseley Group members

Jon Houseley

Jon developed an interest in RNA biology during his PhD research on the pathogenic effects of RNA in the inherited disease Myotonic Dystrophy. However, during his time in Glasgow, first in the Barry lab and then in the Monckton and O’Dell groups, he was surrounded by work on unstable DNA and programmed recombination. His post-doctoral research in the Tollervey lab in Edinburgh started in the biochemistry of RNA degradation, but moved steadily back towards genome alteration with studies on the roles of non-coding RNA in controlling the stability of repetitive DNA. In 2009 Jon started a Wellcome Trust-funded research group at the Babraham Institute studying non-coding RNA biology and copy number variation.

01223 496113

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Latest Publications

Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells.

Cruz C, Della Rosa M, Krueger C

eLife
7 2050-084X: (2018)

PMID: 30274593

Gene expression hallmarks of cellular ageing.

Frenk S, Houseley J

Biogerontology
1573-6768: (2018)

PMID: 29492790

Can aging be beneficial?

Frenk S, Houseley J

Aging
1945-4589: (2017)

PMID: 29074820

Environmental change drives accelerated adaptation through stimulated copy number variation.

Hull RM, Cruz C, Jack CV

PLoS biology
15 1545-7885:e2001333 (2017)

PMID: 28654659

RNA binding by the histone methyltransferases Set1 and Set2.

Sayou C, Millán-Zambrano G, Santos-Rosa H

Molecular and cellular biology
1098-5549: (2017)

PMID: 28483910

Multi-tissue DNA methylation age predictor in mouse.

Stubbs TM, Bonder MJ, Stark AK

Genome biology
18 1474-760X:68 (2017)

PMID: 28399939

Aging yeast gain a competitive advantage on non-optimal carbon sources.

Frenk S, Pizza G, Walker RV

Aging cell
1474-9726: (2017)

PMID: 28247585

TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells.

de la Rica L, Deniz Ö, Cheng KC

Genome biology
17 1474-760X:234 (2016)

PMID: 27863519

Regulation of ribosomal DNA amplification by the TOR pathway.

Jack CV, Cruz C, Hull RM

Proceedings of the National Academy of Sciences of the United States of America
112 1091-6490:9674-9 (2015)

PMID: 26195783

Unexpected DNA loss mediated by the DNA binding activity of ribonuclease A.

Donà F, Houseley J

PloS one
9 1932-6203:e115008 (2014)

PMID: 25502562

The nuclear exosome is active and important during budding yeast meiosis.

Frenk S, Oxley D, Houseley J

PloS one
9 1932-6203:e107648 (2014)

PMID: 25210768