Gavin KelseyGavin obtained a B.Sc. in Biochemistry from King’s College London and then a Ph.D. in Genetics from University College London. Between 1987 and 1995 he was a post-doc at the German Cancer Research Center in Heidelberg, where he held a long-term post-doctoral fellowship from EMBO (1987-1999). In 1995 Gavin joined the Babraham Institute as a Group Leader, holding an MRC senior (non-clinical) fellowship from 1995-2005. He came to Babraham to identify and characterise new imprinted genes.
In addition to discovery of a number of imprinted genes, Gavin investigated imprinted gene effects on growth, metabolism and behaviour, and in human disease. His group currently focuses on understanding how epigenetic states are established in mammalian germ cells and early embryos, and the effects of ageing and diet on the integrity of epigenetic information and its transmission to the next generation.
In addition to his role as a Group Leader at Babraham, Gavin is affiliated to the University of Cambridge Centre for Trophoblast Research (www.trophoblast.cam.ac.uk), and is currently an Associate Editor of Clinical Epigenetics and a Faculty 1000 Member for Epigenetics & Epigenomics.
Rulands S, Lee HJ, Clark SJ
Hanna CW, Demond H, Kelsey G
Human reproduction update
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
Clark SJ, Argelaguet R, Kapourani CA
9 2041-1723:781 (2018)
Hanna CW, Taudt A, Huang J
Nature structural & molecular biology
25 1545-9985:73-82 (2018)
Fonseca Balvís N, Garcia-Martinez S, Pérez-Cerezales S
Biology of reproduction
97 1529-7268:189-196 (2017)
Kelsey G, Stegle O, Reik W
Science (New York, N.Y.)
358 1095-9203:69-75 (2017)
DNA Methylation in Embryo Development: Epigenetic Impact of ART (Assisted Reproductive Technologies).
Canovas S, Ros.s PJ, Kelsey G
BioEssays : news and reviews in molecular, cellular and developmental biology
Hanna CW, Kelsey G
18 1474-760X:177 (2017)
The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program.
Brici D, Zhang Q, Reinhardt S
Development (Cambridge, England)
Gahurova L, Tomizawa SI, Smallwood SA
Epigenetics & chromatin
10 1756-8935:25 (2017)
Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).
Clark SJ, Smallwood SA, Lee HJ
12 1750-2799:534-547 (2017)
DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids.
Canovas S, Ivanova E, Romar R
6 2050-084X: (2017)