Life Sciences Research for Lifelong Health
Kelsey Group members

Gavin Kelsey

Gavin obtained a B.Sc. in Biochemistry from King’s College London and then a Ph.D. in Genetics from University College London. Between 1987 and 1995, he was a post-doc at the German Cancer Research Center in Heidelberg, where he held a long-term post-doctoral fellowship from EMBO (1987-1999). In 1995, Gavin joined the Babraham Institute as a Group Leader, holding an MRC senior (non-clinical) fellowship from 1995-2005. He came to Babraham to develop screens for imprinted genes. In addition to discovery of a number of new imprinted genes, Gavin has investigated imprinted gene effects in growth, metabolism and behaviour, and in human disease. His group currently focuses on understanding how DNA methylation is established in mammalian germ cells and the early embryo, and the effects of ageing and diet on stability of DNA methylation. In addition to his role as a Group Leader at Babraham, Gavin is affiliated to the University of Cambridge Centre for Trophoblast Research ( and is an Associate Member of the EU FP7 Network of Excellence ‘EpiGeneSys’ ( He serves as a member of the BBSRC Grant Committee Pool.

01223 496332

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Latest Publications

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.

Clark SJ, Argelaguet R, Kapourani CA

Nature communications
9 2041-1723:781 (2018)

PMID: 29472610

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.

Hanna CW, Taudt A, Huang J

Nature structural & molecular biology
25 1545-9985:73-82 (2018)

PMID: 29323282

Cultured bovine embryo biopsy conserves methylation marks from original embryo.

Fonseca Balvís N, Garcia-Martinez S, Pérez-Cerezales S

Biology of reproduction
97 1529-7268:189-196 (2017)

PMID: 29044423

Single-cell epigenomics: Recording the past and predicting the future.

Kelsey G, Stegle O, Reik W

Science (New York, N.Y.)
358 1095-9203:69-75 (2017)

PMID: 28983045

DNA Methylation in Embryo Development: Epigenetic Impact of ART (Assisted Reproductive Technologies).

Canovas S, Ross PJ, Kelsey G

BioEssays : news and reviews in molecular, cellular and developmental biology
1521-1878: (2017)

PMID: 28940661

Genomic imprinting beyond DNA methylation: a role for maternal histones.

Hanna CW, Kelsey G

Genome biology
18 1474-760X:177 (2017)

PMID: 28927436

The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program.

Brici D, Zhang Q, Reinhardt S

Development (Cambridge, England)
1477-9129: (2017)

PMID: 28619824

Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.

Gahurova L, Tomizawa SI, Smallwood SA

Epigenetics & chromatin
10 1756-8935:25 (2017)

PMID: 28507606

Establishment and functions of DNA methylation in the germline.

Stewart KR, Veselovska L, Kelsey G

1750-192X: (2016)

PMID: 27659720

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.

Clark SJ, Lee HJ, Smallwood SA

Genome biology
17 1474-760X:72 (2016)

PMID: 27091476