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Will Orchard
Latest Publications
Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels.
Dobnikar L, Taylor AL, Chappell J
Nature communications
9 2041-1723:4567 (2018)
PMID: 30385745
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Koohy H, Bolland DJ, Matheson LS
Genome biology
19 1474-760X:126 (2018)
PMID: 30180872
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.
Choy MK, Javierre BM, Williams SG
Nature communications
9 2041-1723:2526 (2018)
PMID: 29955040
Chromosome contacts in activated T cells identify autoimmune disease candidate genes.
Burren OS, Rubio García A, Javierre BM
Genome biology
18 1474-760X:165 (2017)
PMID: 28870212
Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.
Rubin AJ, Barajas BC, Furlan-Magaril M
Nature genetics
1546-1718: (2017)
PMID: 28805829
Platelet function is modified by common sequence variation in megakaryocyte super enhancers.
Petersen R, Lambourne JJ, Javierre BM
Nature communications
8 2041-1723:16058 (2017)
PMID: 28703137
Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation.
Siersbæk R, Madsen JGS, Javierre BM
Molecular cell
66 1097-4164:420-435.e5 (2017)
PMID: 28475875
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.
Freire-Pritchett P, Schoenfelder S, Várnai C
eLife
6 2050-084X: (2017)
PMID: 28332981
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.
Javierre BM, Burren OS, Wilder SP
Cell
167 1097-4172:1369-1384.e19 (2016)
PMID: 27863249
Defining cell type with chromatin profiling.
Spivakov M, Fraser P
Nature biotechnology
34 1546-1696:1126-1128 (2016)
PMID: 27824844
Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity.
Pancaldi V, Carrillo-de-Santa-Pau E, Javierre BM
Genome biology
17 1474-760X:152 (0)
PMID: 27391817
CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data.
Cairns J, Freire-Pritchett P, Wingett SW
Genome biology
17 1474-760X:127 (2016)
PMID: 27306882