Life Sciences Research for Lifelong Health
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Rafeah Alam

Rafeah graduated from University College London in 2010 with a BSc in Pharmacology. This was followed by a Master’s in Drug Discovery Skills at Kings College London in 2011. As part of her MSc she spent 5 months at AstraZeneca where she worked on assessing the impact of acute cytotoxic treatment on signalling pathways in human tumour models. Following her MSc degree, she spent 2 years working at UCB as a Research Assistant exploring the in vivo potential of some of the therapeutics focused on autoimmune diseases. Her current project as a PhD student at the Babraham Institute involves investigating the effect of overactive p110δ activity on T cell function in a model of a newly discovered primary immunodeficiency ‘’Activated PI3Kδ syndrome’’.

Latest Publications

PI3K induces B-cell development and regulates B cell identity.

Abdelrasoul H, Werner M, Setz CS

Scientific reports
8 2045-2322:1327 (2018)

PMID: 29358580

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Kishore M, Cheung KCP, Fu H

47 1097-4180:875-889.e10 (2017)

PMID: 29166588

Multi-tissue DNA methylation age predictor in mouse.

Stubbs TM, Bonder MJ, Stark AK

Genome biology
18 1474-760X:68 (2017)

PMID: 28399939

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.

Okkenhaug K, Graupera M, Vanhaesebroeck B

Cancer discovery
2159-8290: (2016)

PMID: 27655435

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D

537 1476-4687:539-543 (2016)

PMID: 27626381

PI3Kδ and primary immunodeficiencies.

Lucas CL, Chandra A, Nejentsev S

Nature reviews. Immunology
1474-1741: (2016)

PMID: 27616589

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

Coulter TI, Chandra A, Bacon CM

The Journal of allergy and clinical immunology
1097-6825: (2016)

PMID: 27555459