Systems approaches to the mTOR network

Mammalian target of rapamycin (mTOR) kinase is a central controller of cellular growth and metabolism. mTOR is regulated by nutrients, growth factors, and stress, and acts in two structurally and functionally distinct multiprotein complexes, termed mTOR complex 1 (mTORC1) and mTORC2. Many tumors display mTOR deregulation, making mTOR a prime target in cancer therapy. Our lab studies the control of metabolic homeostasis by mTOR by cell biology, biochemistry, proteomics, and systems biology approaches. In my presentation I will discuss our most recent advances to unravel novel regulatory connections across the mTOR network. I will focus on systems approaches to dissect dynamic kinase network responses to amino acids.

Selected References
Schwarz et al., Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate. Mol Cell Proteomics. 2015 Aug;14(8):2042-55. PMID: 25907765
Thien et al. TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition. Dev Cell. 2015 Mar 9;32(5):617-30. PMID: 25727005.
Thedieck et al. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell. 2013 Aug 15;154(4):859-74. PMID: 23953116.
Dalle Pezze et al. A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. Sci Signal. 2012 Mar 27;5(217):ra25. PMID: 22457331.

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Event Time & Dates


Event Details

Dr Nicolas Le Novère
The Brian Heap Seminar Room