From the gut to the node: a dendritic cell’s journey

From the gut to the node: a dendritic cell’s journey

Dendritic Cells migrate from peripheral tissues to lymph nodes, where they are able to prime naive T cells. To investigate the functions of these migratory DCs in the intestine, we have developed a range of innovative techniques. I will describe two projects: first revealing how the anatomy of  the lymphatic drainage in the intestine allows tissue-specific control of immune responses; and then how subsets of dendritic cells are specialised to drive specific types of T cell responses.

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