PKC and small GTPase signaling in cancer progression
The Kazanietz laboratory studies the mechanisms of signal transduction in cancer progression, with focus on diacylglycerol (DAG) signaling. A main goal is to dissect the involvement of protein kinase C (PKC) serine-threonine kinases in tumorigenesis and metastasis, and understand how they orchestrate important signaling events that control the expression of cancer genes. The laboratory also investigates the role of Rac small GTPases and their regulators, such as P-Rex1, and their associations with cancer pathogenesis.
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