Distinct regulation of T cell dependent antibody responses in chronic infection and inflammation
The generation of large amounts of high quality antibody is fundamental to long term protection against infections. Central to this is the formation of germinal centres, where B cell undergo repeated cycles of somatic hypermutation and affinity maturation. Here they form tight interactions with a specialized subset of CD4+ T cells, T follicular helper cells (TFH), which regulate the quantity, quality and type of antibody generated during an immune response.
My group’s research focuses on the pathways which are critical to the generation and maintenance of Tfh during normal and dysregulated immune responses – in particular cytokine signalling during chronic infection and inflammatory disease.