Identifying new gene regulating networks in immune cells
Gene regulation takes place on multiple levels, enabling immune cells to fine tune their differentiation and functional programs. This includes not mRNA gene transcription, but also splicing, export, translation and mRNA decay. Till to date many transcriptional trans-acting-factors and their respective mechanisms have been identified within immune cells. To identify novel trans-acting factors that rather act downstream of transcription that enable the function function of immune cells, we underwent several approaches within the laboratory, ranging from a first description of all genes that are regulated at the various levels of gene regulation during a T helper cell response, to the pulldown of all RNA-binding proteins in that context, finally also including the description of the in vivo relevance of an RNAse with unknown functions. Therefore, we describe one specific RNA player that is essential for immune homeostasis, as well as a variety of potential newly identified genes that are being post-transcriptionally regulated and trans-acting factors for regulating mRNA.
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