large-scale integration of multiple environmental signals by human immune cells
As part of our ongoing collaboration with the EU Life alliance, the Babraham Institute are proud to host Dr Vassili Soumelis from the Institut Curie, France. Dr Soumelis will be onsite to meet staff and present a Seminar at 13:00hrs in the Brian Heeap Seminar room.
Cells constantly integrate multiple signals in order in order to adapt to their microenvironment. This is particularly important for immune cells, when signals to be integrated are related to a pathogenic threat or to a chronic inflammatory reaction. Such a cellular adaptation is mediated through various biological pathways related to the multiple functions of the cell. This defines the cell as a "multiple input/multiple output" system, which harbors several layers of complexity. We have developed over the years a systems biology framework in order to systematically dissect the effect of combined signals on a diversity of cellular outputs. We have applied this framework to human dendritic cells and T cells, and could establish the concepts of combinatorial flexibility, as well as multimodality in signal integration. Our theoretical and methodological framework can be applied to any cell integrating a combination of physiopathological or pharmacological stimuli.
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25 March, 2015